KEGG   ENZYME: 2.4.2.49Help
Entry
EC 2.4.2.49                 Enzyme                                 

Name
neamine phosphoribosyltransferase;
btrL (gene name);
neoM (gene name)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
neamine:5-phospho-alpha-D-ribose 1-diphosphate phosphoribosyltransferase
Reaction(IUBMB)
neamine + 5-phospho-alpha-D-ribose 1-diphosphate = 5''-phosphoribostamycin + diphosphate [RN:R08898]
Reaction(KEGG)
Substrate
neamine [CPD:C01441];
5-phospho-alpha-D-ribose 1-diphosphate [CPD:C00119]
Product
5''-phosphoribostamycin [CPD:C18004];
diphosphate [CPD:C00013]
Comment
Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. The enzyme requires a divalent metal ion, optimally Mg2+, Ni2+ or Co2+.
History
EC 2.4.2.49 created 2013
Pathway
Butirosin and neomycin biosynthesis
Biosynthesis of antibiotics
Orthology
K13554  
neamine phosphoribosyltransferase
Reference
1  [PMID:17482823]
  Authors
Kudo F, Fujii T, Kinoshita S, Eguchi T.
  Title
Unique O-ribosylation in the biosynthesis of butirosin.
  Journal
Bioorg. Med. Chem. 15 (2007) 4360-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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