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Entry
EC 2.4.2.54                 Enzyme                                 

Name
beta-ribofuranosylphenol 5'-phosphate synthase;
beta-RFAP synthase (incorrect);
beta-RFA-P synthase (incorrect);
AF2089 (gene name);
MJ1427 (gene name);
beta-ribofuranosylhydroxybenzene 5'-phosphate synthase;
4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase (incorrect);
beta-ribofuranosylaminobenzene 5'-phosphate synthase (incorrect);
5-phospho-alpha-D-ribose 1-diphosphate:4-aminobenzoate 5-phospho-beta-D-ribofuranosyltransferase (decarboxylating) (incorrect)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
5-phospho-alpha-D-ribose-1-diphosphate:4-hydroxybenzoate 5-phospho-beta-D-ribofuranosyltransferase (decarboxylating)
Reaction(IUBMB)
5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate [RN:R11102]
Reaction(KEGG)
R11102;
(other) R10337
Show
Substrate
5-phospho-alpha-D-ribose 1-diphosphate [CPD:C00119];
4-hydroxybenzoate [CPD:C00156]
Product
4-(beta-D-ribofuranosyl)phenol 5'-phosphate [CPD:C21107];
CO2 [CPD:C00011];
diphosphate [CPD:C00013]
Comment
The enzyme is involved in biosynthesis of tetrahydromethanopterin in archaea. It was initially thought to use 4-aminobenzoate as a substrate, but was later shown to utilize 4-hydroxybenzoate [4]. The activity is dependent on Mg2+ or Mn2+ [1].
History
EC 2.4.2.54 created 2013, modified 2014, modified 2015
Orthology
K06984  
beta-ribofuranosylaminobenzene 5'-phosphate synthase
Genes
PSEO: 
MMT: 
AFA: 
SULR: 
SAQ: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMP0279(mptG)
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MBA: 
MBY: 
MBW: 
MBAR: 
MMA: 
MMAZ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MEM: 
MBG: 
MEMA: 
MPI: 
MFO: 
MPL: 
MPD: 
MCP_1555(mptG-1) MCP_1942(mptG-2)
MEZ: 
RCI: 
MTH: 
MMG: 
METC: 
MRU: 
mru_1690(mptG)
MEB: 
Abm4_0511(mptG1) Abm4_0513(mptG2)
MMIL: 
sm9_1728(mptG1) sm9_1774(mptG2)
MEYE: 
MEL: 
MEW: 
METH: 
MFC: 
BRM9_1500(mptG)
MFI: 
MFV: 
MKA: 
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
HDL: 
HHB: 
HHI: 
HAH_1044(ghmP)
HHN: 
HAB: 
NPH: 
NMO: 
HUT: 
HTI: 
HMU: 
HJE: 
HSU: 
HSF: 
HWA: 
HWC: 
HVO: 
HME: 
HGI: 
HBO: 
HTU: 
NMG: 
HXA: 
NAT: 
NPE: 
NGE: 
HRU: 
NOU: 
SALI: 
HLR: 
PHO: 
PH0227(PH0227) PH1228(PH1228)
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TON: 
TGA: 
TGAM_1652(ghmP)
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
TGY: 
THV: 
PPAC: 
APE: 
ACJ: 
SHC: 
IHO: 
IIS: 
DMU: 
DFD: 
TAG: 
IAG: 
HBU: 
PFM: 
PDL: 
SSO: 
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
AHO: 
ASC: 
CLG: 
FFO: 
CSU: 
LOKI: 
HAH: 
 » show all
Taxonomy
Reference
1  [PMID:9698382]
  Authors
Rasche ME, White RH
  Title
Mechanism for the enzymatic formation of 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate during the biosynthesis of methanopterin.
  Journal
Biochemistry. 37 (1998) 11343-51.
Reference
2  [PMID:12142414]
  Authors
Scott JW, Rasche ME
  Title
Purification, overproduction, and partial characterization of beta-RFAP synthase, a key enzyme in the methanopterin biosynthesis pathway.
  Journal
J. Bacteriol. 184 (2002) 4442-8.
  Sequence
[afu:AF_2089]
Reference
3  [PMID:15262968]
  Authors
Dumitru RV, Ragsdale SW
  Title
Mechanism of 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase, a key enzyme in the methanopterin biosynthetic pathway.
  Journal
J. Biol. Chem. 279 (2004) 39389-95.
  Sequence
[mja:MJ_1427]
Reference
4  [PMID:21634403]
  Authors
White RH
  Title
The conversion of a phenol to an aniline occurs in the biochemical formation of the 1-(4-aminophenyl)-1-deoxy-D-ribitol moiety in methanopterin.
  Journal
Biochemistry. 50 (2011) 6041-52.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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