KEGG   ENZYME: 2.4.2.57Help
Entry
EC 2.4.2.57                 Enzyme                                 

Name
AMP phosphorylase;
AMPpase;
nucleoside monophosphate phosphorylase;
deoA (gene name)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
AMP:phosphate alpha-D-ribosyl 5'-phosphate-transferase
Reaction(IUBMB)
(1) AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate [RN:R10836];
(2) CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate [RN:R10837];
(3) UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate [RN:R10838]
Reaction(KEGG)
Substrate
AMP [CPD:C00020];
phosphate [CPD:C00009];
CMP [CPD:C00055];
UMP [CPD:C00105]
Product
adenine [CPD:C00147];
alpha-D-ribose 1,5-bisphosphate [CPD:C01151];
cytosine [CPD:C00380];
uracil [CPD:C00106]
Comment
The enzyme from archaea is involved in AMP metabolism and CO2 fixation through type III RubisCO enzymes. The activity with CMP and UMP requires activation by cAMP [2].
History
EC 2.4.2.57 created 2014
Orthology
K18931  
AMP phosphorylase
Genes
SRB: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMP0327(deoA)
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MA_3242(deoA)
MBA: 
MBY: 
MBW: 
MBAR: 
MBAK: 
MMA: 
MMAZ: 
MMJ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
MEMA: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MEZ: 
Mtc_0258(deoA)
RCI: 
RCIX1126(deoA)
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
NPH: 
NP_3958A(deoA)
HVO: 
HME: 
HFX_0962(deoA)
HGI: 
HBO: 
NMG: 
TAR: 
MAX: 
MER: 
MEAR: 
MARC: 
PHO: 
PH1598(PH1598)
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
PYC: 
TKO: 
TON: 
TGA: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
TGY: 
THV: 
TCH: 
PPAC: 
ABI: 
ACF: 
SHC: 
DKA: 
DMU: 
DFD: 
TAG: 
THG: 
HBU: 
PDL: 
TPE: 
THB: 
TCB: 
LOKI: 
BARC: 
AGW: 
 » show all
Taxonomy
Reference
1  [PMID:17303759]
  Authors
Sato T, Atomi H, Imanaka T
  Title
Archaeal type III RuBisCOs function in a pathway for AMP metabolism.
  Journal
Science. 315 (2007) 1003-6.
  Sequence
[tko:TK0352]
Reference
2  [PMID:23065974]
  Authors
Aono R, Sato T, Yano A, Yoshida S, Nishitani Y, Miki K, Imanaka T, Atomi H
  Title
Enzymatic characterization of AMP phosphorylase and ribose-1,5-bisphosphate isomerase functioning in an archaeal AMP metabolic pathway.
  Journal
J. Bacteriol. 194 (2012) 6847-55.
  Sequence
[tko:TK0352]
Reference
3  [PMID:23659790]
  Authors
Nishitani Y, Aono R, Nakamura A, Sato T, Atomi H, Imanaka T, Miki K
  Title
Structure analysis of archaeal AMP phosphorylase reveals two unique modes of dimerization.
  Journal
J. Mol. Biol. 425 (2013) 2709-21.
  Sequence
[tko:TK0352]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system