KEGG   ENZYME: 2.4.99.11Help
Entry
EC 2.4.99.11                Enzyme                                 

Name
lactosylceramide alpha-2,6-N-sialyltransferase;
cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase;
CMP-acetylneuraminate-lactosylceramide-sialyltransferase;
CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase;
CMP-sialic acid:lactosylceramide sialyltransferase;
CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase;
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide alpha-(2->6)-N-acetylneuraminyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide alpha-(2->6)-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Reaction(KEGG)
(other) R03489 R06121(G)
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Substrate
CMP-N-acetylneuraminate [CPD:C00128];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
History
EC 2.4.99.11 created 1992
Reference
1  [PMID:2460092]
  Authors
Albarracin I, Lassaga FE, Caputto R.
  Title
Purification and characterization of an endogenous inhibitor of the sialyltransferase CMP-N-acetylneuraminate: lactosylceramide alpha 2,6-N-acetylneuraminyltransferase (EC 2.4.99.-).
  Journal
Biochem. J. 254 (1988) 559-65.
Reference
2  [PMID:606237]
  Authors
Landa CA, Maccioni HJ, Arce A, Caputto R.
  Title
The biosynthesis of brain gangliosides. Separation of membranes with different ratios of ganglioside sialylating activity to gangliosides.
  Journal
Biochem. J. 168 (1977) 325-32.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
55071-95-9

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