KEGG   ENZYME: 2.4.99.6Help
Entry
EC 2.4.99.6                 Enzyme                                 

Name
N-acetyllactosaminide alpha-2,3-sialyltransferase;
cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase;
alpha2->3 sialyltransferase (ambiguous);
SiaT (ambiguous);
CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase;
neolactotetraosylceramide alpha-2,3-sialyltransferase;
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-glycoprotein alpha-(2->3)-N-acetylneuraminyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetyl-beta-neuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R (2->3)-N-acetyl-alpha-neuraminyltransferase (configuration-inverting)
Reaction(IUBMB)
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R [RN:R04596 R09297]
Reaction(KEGG)
R04596 R09297(G);
(other) R04656 R06026(G) R06037(G) R06153(G)
Show
Substrate
CMP-N-acetyl-beta-neuraminate [CPD:C00128];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R [CPD:C00694]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R
Comment
The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids. The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1 [2].
History
EC 2.4.99.6 created 1984, modified 1986 (EC 2.4.99.10 created 1986, incorporated 2017)
Pathway
Various types of N-glycan biosynthesis
Other types of O-glycan biosynthesis
Mannose type O-glycan biosynthesis
Glycosaminoglycan biosynthesis - keratan sulfate
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways
Orthology
K00781  
neolactotetraosylceramide alpha-2,3-sialyltransferase (sialyltransferase 6)
K03792  
neolactotetraosylceramide alpha-2,3-sialyltransferase (sialyltransferase 10)
Genes
HSA: 
10402(ST3GAL6) 6487(ST3GAL3)
PTR: 
456832(ST3GAL3) 460547(ST3GAL6)
PPS: 
100977718(ST3GAL6) 100982060(ST3GAL3)
GGO: 
101126091(ST3GAL3) 101133620(ST3GAL6)
PON: 
NLE: 
100583585(ST3GAL6) 100596717(ST3GAL3)
MCC: 
699096(ST3GAL6) 703599(ST3GAL3)
MCF: 
102115716(ST3GAL6) 102124772(ST3GAL3)
CSAB: 
103224957(ST3GAL3) 103228470(ST3GAL6)
RRO: 
104654524(ST3GAL6) 104669039(ST3GAL3)
RBB: 
108516678(ST3GAL6) 108535692(ST3GAL3)
CJC: 
100389235(ST3GAL6) 100411797(ST3GAL3)
SBQ: 
MMU: 
20441(St3gal3) 54613(St3gal6)
RNO: 
304023(St3gal6) 64445(St3gal3)
CGE: 
100689187(St3gal3) 100771326(St3gal6)
NGI: 
103732633(St3gal6) 103743864(St3gal3)
HGL: 
101706310(St3gal6) 101716398(St3gal3)
CCAN: 
109681562 109681564(St3gal3) 109696030(St3gal6)
OCU: 
100339165(ST3GAL6) 100353106(ST3GAL3)
TUP: 
102481523(ST3GAL6) 102486753(ST3GAL3)
CFA: 
478535(ST3GAL6) 610736(ST3GAL3)
AML: 
100472631(ST3GAL3) 100481119(ST3GAL6)
UMR: 
103670807(ST3GAL3) 103673244(ST3GAL6)
FCA: 
101081911(ST3GAL3) 101091552(ST3GAL6)
PTG: 
102952023(ST3GAL6) 102966623(ST3GAL3)
AJU: 
106970220(ST3GAL3) 106982524(ST3GAL6)
BTA: 
444859(ST3GAL3) 444860(ST3GAL6)
BOM: 
102265994(ST3GAL6) 102284552(ST3GAL3)
BIU: 
109556395(ST3GAL3) 109564929(ST3GAL6)
PHD: 
102337048(ST3GAL6) 102343639(ST3GAL3)
CHX: 
102168794(ST3GAL3) 102175162(ST3GAL6)
OAS: 
101106812(ST3GAL6) 101112269(ST3GAL3)
SSC: 
100739492(ST3GAL6) 396619(ST3GAL3)
CFR: 
102516778(ST3GAL6) 102517093(ST3GAL3)
CDK: 
105087739(ST3GAL6) 105090902(ST3GAL3)
BACU: 
103001584(ST3GAL6) 103003034(ST3GAL3)
LVE: 
103078993(ST3GAL6) 103083644(ST3GAL3)
ECB: 
100053104(ST3GAL3) 100062218(ST3GAL6)
EPZ: 
EAI: 
106824252(ST3GAL6) 106847915(ST3GAL3)
MYB: 
102245915(ST3GAL3) 102260204(ST3GAL6)
MYD: 
102754272(ST3GAL6) 102773348(ST3GAL3)
HAI: 
109377051(ST3GAL6) 109383404(ST3GAL3)
RSS: 
109457885(ST3GAL3) 109460793(ST3GAL6)
PALE: 
102883140(ST3GAL3) 102889744(ST3GAL6)
LAV: 
100668469(ST3GAL3) 100672752(ST3GAL6)
MDO: 
100017812(ST3GAL6) 100025401(ST3GAL3)
SHR: 
100917951(ST3GAL3) 100923762(ST3GAL6)
OAA: 
GGA: 
395138(ST3GAL6) 424572(ST3GAL3)
MGP: 
100541741(ST3GAL6) 100543009(ST3GAL3)
CJO: 
107317545(ST3GAL3) 107320596(ST3GAL6)
APLA: 
101802079(ST3GAL6) 101804175(ST3GAL3)
ACYG: 
106033989(ST3GAL3) 106038338(ST3GAL6)
TGU: 
100221242(ST3GAL3) 100222736(ST3GAL6)
GFR: 
102034732(ST3GAL3) 102043783(ST3GAL6)
FAB: 
101807588(ST3GAL3) 101815960(ST3GAL6)
PHI: 
102099818(ST3GAL6) 102104267(ST3GAL3)
CCW: 
104687090(ST3GAL6) 104695266(ST3GAL3)
FPG: 
101915399(ST3GAL6) 101917466(ST3GAL3)
FCH: 
102055195(ST3GAL3) 102060181(ST3GAL6)
CLV: 
102083691(ST3GAL6) 102089431(ST3GAL3)
AAM: 
106484925(ST3GAL3) 106490642(ST3GAL6)
ASN: 
102377903(ST3GAL6) 102387225(ST3GAL3)
AMJ: 
102570018(ST3GAL6) 102570899(ST3GAL3)
PSS: 
102458402(ST3GAL3) 102462369(ST3GAL6)
CMY: 
102937505(ST3GAL3) 102947450(ST3GAL6)
CPIC: 
101932642(ST3GAL6) 101943704(ST3GAL3)
ACS: 
100556902(st3gal3) 100557291(st3gal6)
PBI: 
103048808(ST3GAL3) 103051166(ST3GAL6)
GJA: 
107110020(ST3GAL6) 107120284(ST3GAL3)
XLA: 
100462908(st3gal-iii) 108709199 108715547(st3Gal-III) 398745(st3gal6.L) 398746(st3gal3.S)
XTR: 
402789(st3gal3) 402790(st3gal6)
NPR: 
DRE: 
407659(st3gal3b)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
445973(st3gal3)
TNG: 
LCO: 
NCC: 
MZE: 
101484929(st3gal3)
OLA: 
100049527(st3gal3)
XMA: 
102237009(st3gal3)
CSEM: 
LCF: 
SASA: 
ELS: 
SFM: 
108923813(st3gal3)
LCM: 
102351151(ST3GAL3) 102356485(ST3GAL6)
CMK: 
103174609(st3gal3) 103180110(st3gal6)
BFO: 
SPU: 
SKO: 
 » show all
Taxonomy
Reference
1  [PMID:7204397]
  Authors
Van den Eijnden DH, Schiphorst WE.
  Title
Detection of beta-galactosyl(1 leads to 4)N-acetylglucosaminide alpha(2 leads to 3)-sialyltransferase activity in fetal calf liver and other tissues.
  Journal
J. Biol. Chem. 256 (1981) 3159-62.
Reference
2  [PMID:7130178]
  Authors
Basu M, Basu S, Stoffyn A, Stoffyn P.
  Title
Biosynthesis in vitro of sialyl(alpha 2-3)neolactotetraosylceramide by a sialyltransferase from embryonic chicken brain.
  Journal
J. Biol. Chem. 257 (1982) 12765-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
77537-85-0

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