KEGG   ENZYME: 2.4.99.8Help
Entry
EC 2.4.99.8                 Enzyme                                 

Name
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase;
cytidine monophosphoacetylneuraminate-ganglioside GM3;
alpha-2,8-sialyltransferase;
ganglioside GD3 synthase;
ganglioside GD3 synthetase sialyltransferase;
CMP-NeuAc:LM1(alpha2-8) sialyltranferase;
GD3 synthase;
SAT-2
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-(2->3)-beta-D-galactoside alpha-(2->8)-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R [RN:R04564]
Reaction(KEGG)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Comment
Gangliosides act as acceptors.
History
EC 2.4.99.8 created 1984, modified 1986
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K03371  alpha-N-acetyl-neuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)
Genes
HSA: 6489(ST8SIA1)
PTR: 465341(ST8SIA1)
PPS: 100970748(ST8SIA1)
GGO: 101134419(ST8SIA1)
PON: 100455082(ST8SIA1)
NLE: 100588840(ST8SIA1)
MCC: 706707(ST8SIA1)
MCF: 102118571(ST8SIA1)
CSAB: 103218743(ST8SIA1)
RRO: 104660754(ST8SIA1)
RBB: 108541110(ST8SIA1)
SBQ: 101042881(ST8SIA1)
MMU: 20449(St8sia1)
RNO: 25280(St8sia1)
CGE: 100768920(St8sia1)
NGI: 103736726(St8sia1)
HGL: 101696963(St8sia1)
CCAN: 109700114(St8sia1)
OCU: 100351155(ST8SIA1)
TUP: 102468919(ST8SIA1)
CFA: 477672(ST8SIA1)
AML: 100464397(ST8SIA1)
UMR: 103665233(ST8SIA1)
ORO: 101366887(ST8SIA1)
FCA: 101093029(ST8SIA1)
PTG: 102962819(ST8SIA1)
AJU: 106967976(ST8SIA1)
BTA: 282352(ST8SIA1)
BOM: 102273511(ST8SIA1)
BIU: 109559591(ST8SIA1)
PHD: 102334137(ST8SIA1)
CHX: 102187381(ST8SIA1)
OAS: 101117321(ST8SIA1)
SSC: 100625270(ST8SIA1)
CFR: 102512853(ST8SIA1)
CDK: 105096526(ST8SIA1) 105100071
BACU: 103009301(ST8SIA1)
LVE: 103076775(ST8SIA1)
OOR: 101285691(ST8SIA1)
ECB: 100064415(ST8SIA1)
EPZ: 103540886 103554941(ST8SIA1)
EAI: 106825576(ST8SIA1)
MYB: 102249041(ST8SIA1)
MYD: 102758116(ST8SIA1) 102769678
HAI: 109375156(ST8SIA1) 109377322
RSS: 109450570(ST8SIA1)
PALE: 102892181(ST8SIA1)
LAV: 100659787(ST8SIA1)
TMU: 101359255
MDO: 100011205(ST8SIA1)
SHR: 100920916(ST8SIA1)
OAA: 100080234
GGA: 395860(ST8SIA1)
MGP: 100547921(ST8SIA1)
CJO: 107317147(ST8SIA1)
APLA: 101797310(ST8SIA1)
ACYG: 106038258(ST8SIA1)
TGU: 100225976(ST8SIA1)
GFR: 102037290(ST8SIA1)
FAB: 101806998(ST8SIA1)
PHI: 102111773(ST8SIA1)
PMAJ: 107204564(ST8SIA1)
CCW: 104692305(ST8SIA1)
FPG: 101922614(ST8SIA1)
FCH: 102056471(ST8SIA1)
CLV: 102093502(ST8SIA1)
EGZ: 104135090(ST8SIA1)
AAM: 106488295(ST8SIA1)
ASN: 102378302(ST8SIA1)
AMJ: 102562267(ST8SIA1)
PSS: 102462829(ST8SIA1)
CMY: 102943965(ST8SIA1)
CPIC: 101937464(ST8SIA1)
ACS: 100337536(st8sia1)
PVT: 110091198(ST8SIA1)
PBI: 103065178(ST8SIA1)
GJA: 107105667 107114868(ST8SIA1)
XLA: 108712513 398735(st8sia1.L)
XTR: 444887(st8sia1)
DRE: 553210(st8sia1)
SANH: 107689712(st8sia1)
IPU: 108279455(ST8SIA1) 108279490
AMEX: 103035159(st8sia1)
TRU: 445978(st8sia1)
LCO: 104923709(st8sia1) 109141779
NCC: 104958359(st8sia1)
MZE: 101480363(st8sia1)
OLA: 100049518(st8sia1)
XMA: 102218717(st8sia1)
PRET: 103459243(st8sia1)
NFU: 107379800(st8sia1)
CSEM: 103382754(st8sia1)
LCF: 108879661(st8sia1)
HCQ: 109523778(st8sia1)
BPEC: 110170325(st8sia1)
ELS: 105020361(st8sia1)
LCM: 102350065(ST8SIA1)
CMK: 103181078(st8sia1)
 » show all
Taxonomy
Reference
1  [PMID:7407217]
  Authors
Eppler CM, Morre DJ, Keenan TW.
  Title
Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides.
  Journal
Biochim. Biophys. Acta. 619 (1980) 332-43.
Reference
2  [PMID:3838172]
  Authors
Higashi H, Basu M, Basu S.
  Title
Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain.
  Journal
J. Biol. Chem. 260 (1985) 824-8.
Reference
3  [PMID:4044605]
  Authors
McCoy RD, Vimr ER, Troy FA.
  Title
CMP-NeuNAc:poly-alpha-2,8-sialosyl sialyltransferase and the biosynthesis of polysialosyl units in neural cell adhesion molecules.
  Journal
J. Biol. Chem. 260 (1985) 12695-9.
Reference
4  [PMID:6766128]
  Authors
Yohe HC, Yu RK.
  Title
In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a.
  Journal
J. Biol. Chem. 255 (1980) 608-13.
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.8
IUBMB Enzyme Nomenclature: 2.4.99.8
ExPASy - ENZYME nomenclature database: 2.4.99.8
BRENDA, the Enzyme Database: 2.4.99.8
CAS: 67339-00-8

DBGET integrated database retrieval system