KEGG   ENZYME: 2.4.99.9Help
Entry
EC 2.4.99.9                 Enzyme                                 
Name
lactosylceramide alpha-2,3-sialyltransferase;
cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase;
CMP-acetylneuraminate-lactosylceramide-sialyltransferase;
CMP-acetylneuraminic acid:lactosylceramide sialyltransferase;
CMP-sialic acid:lactosylceramide-sialyltransferase;
cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase;
ganglioside GM3 synthetase;
GM3 synthase;
GM3 synthetase;
SAT 1;
CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase;
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide alpha-(2->3)-N-acetylneuraminyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide alpha-(2->3)-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03488 R05937]
Reaction(KEGG)
R03488 R05937(G);
(other) R04630 R04647 R06003(G) R06007(G)
Show
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
Lactose cannot act as acceptor.
Pathway
Glycosphingolipid biosynthesis - ganglio series
Metabolic pathways
Orthology
K03370  
lactosylceramide alpha-2,3-sialyltransferase (sialyltransferase 9)
Genes
HSA: 
8869(ST3GAL5)
PTR: 
459371(ST3GAL5)
PPS: 
100974771(ST3GAL5)
GGO: 
101127197(ST3GAL5)
PON: 
100458488(ST3GAL5)
MCC: 
696842(ST3GAL5)
MMU: 
20454(St3gal5)
RNO: 
83505(St3gal5)
CFA: 
612022(ST3GAL5)
AML: 
100469790(ST3GAL5)
FCA: 
101092099(ST3GAL5)
BTA: 
404164(ST3GAL5)
SSC: 
100625751
ECB: 
100067118(ST3GAL5)
MDO: 
100029907
SHR: 
100919035(ST3GAL5)
OAA: 
100080527
GGA: 
407775(ST3GAL5)
MGP: 
100547934
TGU: 
100229190(ST3GAL5)
ACS: 
100561853
XTR: 
100329191(st3gal5)
DRE: 
394230(st3gal5)
TRU: 
777948(st3gal5)
OLA: 
101156587
 » show all
Taxonomy
Reference
1  [PMID:4631392]
  Authors
Basu S, Kaufman B, Roseman S.
  Title
Enzymatic synthesis of glucocerebroside by a glucosyltransferase from embryonic chicken brain.
  Journal
J. Biol. Chem. 248 (1973) 1388-94.
  Organism
Gallus gallus [GN:gga]
Reference
2  [PMID:4022]
  Authors
Fishman PH, Bradley RM, Henneberry RC.
  Title
Butyrate-induced glycolipid biosynthesis in HeLa cells: properties of the induced sialyltransferase.
  Journal
Arch. Biochem. Biophys. 172 (1976) 618-26.
  Organism
Rattus norvegicus [GN:rno], Homo sapiens [GN:hsa]
Reference
3  [PMID:3838172]
  Authors
Higashi H, Basu M, Basu S.
  Title
Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain.
  Journal
J. Biol. Chem. 260 (1985) 824-8.
  Organism
Gallus gallus [GN:gga]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
125752-90-1
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