KEGG   ENZYME: 2.5.1.101Help
Entry
EC 2.5.1.101                Enzyme                                 

Name
N,N'-diacetyllegionaminate synthase;
neuB (gene name);
legI (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
phosphoenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O = N,N'-diacetyllegionaminate + phosphate [RN:R10304]
Reaction(KEGG)
Substrate
2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose [CPD:C20424];
phosphoenolpyruvate [CPD:C00074];
H2O [CPD:C00001]
Product
N,N'-diacetyllegionaminate [CPD:C20418];
phosphate [CPD:C00009]
Comment
Requires a divalent metal such as Mn2+. Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni, where it is involved in the biosynthesis of legionaminic acid, a virulence-associated, cell surface sialic acid-like derivative.
History
EC 2.5.1.101 created 2012
Pathway
Amino sugar and nucleotide sugar metabolism
Orthology
K18430  
N,N'-diacetyllegionaminate synthase
Genes
AMK: 
ASP: 
LPN: 
lpg0752(neuB)
LPH: 
LPV_0878(neuB)
LPO: 
LPO_0833(neuB)
LPU: 
LPM: 
LP6_0732(neuB)
LPF: 
lpl0789(neuB)
LPP: 
lpp0818(neuB)
LPC: 
LPC_2540(neuB)
LPA: 
LPE: 
FPH: 
FPI: 
BF30_1411(neuB)
FPX: 
KU46_147(neuB)
TAO: 
TEE: 
TBN: 
THO: 
HCP: 
HCB: 
TDN: 
SULR: 
CJE: 
Cj1327(neuB2)
CJB: 
BN148_1327(neuB2)
CJI: 
CJSA_1263(neuB2)
CJS: 
CJP: 
CJEJ: 
CJEU: 
CJEN: 
CJEI: 
CJER: 
CJY: 
QZ67_01463(legI_2)
CJQ: 
UC78_1270(legI)
CJL: 
CJW: 
CJR: 
CJE1516(ptmC)
CJD: 
CJZ: 
CJX: 
CCO: 
CLA: 
Cla_1235(ptmC)
CLL: 
CCOL: 
CCC: 
CCQ: 
CCF: 
CCY: 
CCOI: 
CCOF: 
CAJ: 
CIS: 
CINS_1194(legI)
CVO: 
CVOL_1214(legI)
CSM: 
CSF: 
ABT: 
ARC: 
GSB: 
DDN: 
DAS: 
DTO: 
ALI: 
MAGQ: 
PEL: 
BST: 
FPN: 
PPY: 
PTA: 
PDU: 
PPEO: 
EFC: 
EFAU: 
EFU: 
AUI: 
CARC: 
CNO: 
CBL: 
CBB: 
CBN: 
CCB: 
CTH: 
CTX: 
CCL: 
BPB: 
bpr_I0428(neuB1)
CLE: 
CSH: 
CST: 
DDL: 
DMT: 
DOR: 
AWO: 
TIT: 
TXY: 
TSH: 
HOR: 
HPK: 
ARI: 
SYW: 
SYNW0448(neuB)
FGI: 
TPED: 
SCD: 
LIL: 
LA_1609(spsE)
LIE: 
LIF_A1296(spsE)
LIC: 
LIC_12173(neuB)
LST: 
BDH: 
TFO: 
BFO_1066(neuB)
PEP: 
SCN: 
FBT: 
COL: 
NDO: 
POM: 
PPH: 
PMX: 
TTK: 
TST_1473(neuB)
DDF: 
MMAK: 
MSJ: 
MSW: 
MFO: 
MEW: 
NIN: 
AGW: 
 » show all
Taxonomy
Reference
1  [PMID:18275154]
  Authors
Glaze PA, Watson DC, Young NM, Tanner ME
  Title
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
  Journal
Biochemistry. 47 (2008) 3272-82.
  Sequence
[lpn:lpg0752]
Reference
2  [PMID:19282391]
  Authors
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM
  Title
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel  GDP-linked precursors.
  Journal
Glycobiology. 19 (2009) 715-25.
  Sequence
[cje:Cj1327]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system