KEGG   ENZYME: 2.5.1.101Help
Entry
EC 2.5.1.101                Enzyme                                 

Name
N,N'-diacetyllegionaminate synthase;
neuB (gene name);
legI (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
phosphoenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O = N,N'-diacetyllegionaminate + phosphate [RN:R10304]
Reaction(KEGG)
Substrate
2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose [CPD:C20424];
phosphoenolpyruvate [CPD:C00074];
H2O [CPD:C00001]
Product
N,N'-diacetyllegionaminate [CPD:C20418];
phosphate [CPD:C00009]
Comment
Requires a divalent metal such as Mn2+. Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni, where it is involved in the biosynthesis of legionaminic acid, a virulence-associated, cell surface sialic acid-like derivative.
History
EC 2.5.1.101 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K18430  N,N'-diacetyllegionaminate synthase
Genes
PMAI: CF386_03205(neuB)
PTU: PTUN_a3149(neuB)
MLQ: ASQ50_04385
ASP: AOR13_2481
ASQ: AVL57_11080
AAW: AVL56_10220
LPN: lpg0752(neuB)
LPH: LPV_0878(neuB)
LPO: LPO_0833(neuB)
LPU: LPE509_02459
LPM: LP6_0732(neuB)
LPF: lpl0789(neuB)
LPP: lpp0818(neuB)
LPC: LPC_2540(neuB)
LPA: lpa_01160
LPE: lp12_0762
LCD: clem_09455(neuB_2)
FPH: Fphi_1167
FPI: BF30_1411(neuB)
FPX: KU46_147(neuB)
FHA: CDV26_09130(neuB)
TEE: Tel_08595
AEM: CK911_04505(neuB)
TBN: TBH_C0740
METR: BSY238_2009(neuB)
HCP: HCN_1148
SULR: B649_08560
CJE: Cj1327(neuB2)
CJB: BN148_1327(neuB2)
CJI: CJSA_1263(neuB2)
CJS: CJS3_1421
CJEJ: N564_02255
CJEU: N565_02345
CJEN: N755_02405
CJEI: N135_01415
CJER: H730_07590
CJY: QZ67_01463(legI_2)
CJQ: UC78_1270(legI)
CJR: CJE1516(ptmC)
CJD: JJD26997_0385(ptmC)
CCO: CCC13826_2303(legI)
CCOC: CCON33237_1630(legI)
CLA: Cla_1235(ptmC)
CCQ: N149_1290
CCF: YSQ_02215
CCY: YSS_07200
CCOI: YSU_02250
CCOF: VC76_06660(legI)
CCOO: ATE51_00910(legI)
CAJ: CIG1485E_0029(legI)
CIS: CINS_1194(legI)
CVO: CVOL_1214(legI)
CSM: CSUB8521_1417(legI)
CSF: CSUB8523_1517(legI)
CHV: CHELV3228_1655(legI)
CLX: CLAN_1241(legI)
ABT: ABED_0620
ARC: ABLL_0809
DAS: Daes_1985
DTO: TOL2_C35400(neuB)
RHT: NT26_3141(neuB)
DEI: C4375_03855(neuB)
BST: GYO_4022
PPY: PPE_04401
EFU: HMPREF0351_10916(neuB)
CARC: NY10_960
CBL: CLK_2101
CBB: CLD_1854
CBN: CbC4_0996
CTAE: BGI42_06575(neuB)
CTH: Cthe_2641
BPB: bpr_I0428(neuB1)
AWO: Awo_c24840(neuB)
CTHM: CFE_2539
TIT: Thit_0481
TSH: Tsac_2668
SYW: SYNW0448(neuB)
TPED: TPE_0201
LIL: LA_1609(spsE)
LIE: LIF_A1296(spsE)
LIC: LIC_12173(neuB)
TFO: BFO_1066(neuB)
MARB: CJ263_08140(neuB)
NDO: DDD_3554
TJE: TJEJU_1144(legI)
PPH: Ppha_0527
PMX: PERMA_1627(neuB)
TTK: TST_1473(neuB)
 » show all
Taxonomy
Reference
1  [PMID:18275154]
  Authors
Glaze PA, Watson DC, Young NM, Tanner ME
  Title
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
  Journal
Biochemistry. 47 (2008) 3272-82.
  Sequence
[lpn:lpg0752]
Reference
2  [PMID:19282391]
  Authors
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM
  Title
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel  GDP-linked precursors.
  Journal
Glycobiology. 19 (2009) 715-25.
  Sequence
[cje:Cj1327]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.101
IUBMB Enzyme Nomenclature: 2.5.1.101
ExPASy - ENZYME nomenclature database: 2.5.1.101
BRENDA, the Enzyme Database: 2.5.1.101

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