KEGG   ENZYME: 2.5.1.103Help
Entry
EC 2.5.1.103                Enzyme                                 

Name
presqualene diphosphate synthase;
SSL-1 (gene name);
hpnD (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase (presqualene diphosphate-forming)
Reaction(IUBMB)
2 (2E,6E)-farnesyl diphosphate = presqualene diphosphate + diphosphate [RN:R00702]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
presqualene diphosphate [CPD:C03428];
diphosphate [CPD:C00013]
Comment
Isolated from the green alga Botryococcus braunii BOT22. Unlike EC 2.5.1.21, squalene synthase, where squalene is formed in one step from farnesyl diphosphate, in this alga the intermediate presqualene diphosphate is generated and released by this enzyme. This compound is then converted into either squalene (by EC 1.3.1.96, Botryococcus squalene synthase) or botryococcene (EC 1.3.1.97, botryococcene synthase).
History
EC 2.5.1.103 created 2012
Orthology
K21151  presqualene diphosphate synthase
K21678  presqualene diphosphate synthase
Genes
RPJ: N234_32515
REU: Reut_B4953
REH: H16_B2206(h16_B2206)
CNC: CNE_2c21840
RME: Rmet_4149(crtB)
CTI: RALTA_B1982(crtB)
CBW: RR42_s2400
CCUP: BKK81_26335
CUP: BKK80_29980
CUU: BKK79_20630
BMA: BMAA2102
BMAL: DM55_3713(hpnD)
BMAE: DM78_4587(hpnD)
BMAQ: DM76_4408(hpnD)
BMAI: DM57_14645
BMAF: DM51_3765(hpnD)
BMAZ: BM44_3672(hpnD)
BMAB: BM45_4449(hpnD)
BPS: BPSS2340
BPSE: BDL_5819(hpnD)
BPSM: BBQ_3759(hpnD)
BPSU: BBN_5841(hpnD)
BPSD: BBX_4988(hpnD)
BPK: BBK_5126(hpnD)
BPSH: DR55_5385(hpnD)
BPSA: BBU_3645(hpnD)
BPSO: X996_5155(hpnD)
BUT: X994_4704(hpnD)
BTQ: BTQ_3276(hpnD)
BTJ: BTJ_4308(hpnD)
BTZ: BTL_5109(hpnD)
BTD: BTI_4771(hpnD)
BTV: BTHA_5107(hpnD)
BTHE: BTN_4770(hpnD)
BTHM: BTRA_5038(hpnD)
BTHA: DR62_4874
BTHL: BG87_5105(hpnD)
BOK: DM82_3977(hpnD)
BOC: BG90_4050(hpnD)
BVE: AK36_4903(hpnD)
BCN: Bcen_5178
BCJ: BCAM2833
BCEN: DM39_5011(hpnD)
BCEW: DM40_3398(hpnD)
BCEO: I35_6713
BAM: Bamb_4953
BMU: Bmul_3173
BMK: DM80_4551(hpnD)
BMUL: NP80_3381(hpnD)
BCT: GEM_5579
BCED: DM42_5155(hpnD)
BDL: AK34_4972(hpnD)
BCON: NL30_18015
BUB: BW23_4003(hpnD)
BLAT: WK25_29570
BTEI: WS51_10755
BSEM: WJ12_34030
BPSL: WS57_00075
BMEC: WJ16_32505
BSTG: WT74_32870
BGU: KS03_3645(hpnD)
BGO: BM43_6722(hpnD)
BYI: BYI23_B013700(hpnD)
BUK: MYA_3463
BUE: BRPE67_BCDS00660(hpnD)
BUL: BW21_4300(hpnD)
BXE: Bxe_B0010
BXB: DR64_5374(hpnD)
BPH: Bphy_4139
BFN: OI25_5472(hpnD)
PARB: CJU94_28545(hpnD)
PHS: C2L64_18365(hpnD)
PTER: C2L65_16200(hpnD)
PPNO: DA70_09100
PPNM: LV28_21705
PPUL: RO07_16095
PSPU: NA29_21055
PAPI: SG18_00205
RHI: NGR_a00440(hpnD)
BJA: blr3002
BRA: BRADO2628
BBT: BBta_2967
BRS: S23_49950(hpnD)
AOL: S58_49910
BRAD: BF49_1690
BRK: CWS35_18215(hpnD)
RPA: RPA3742
RPB: RPB_1724
RPC: RPC_1718
RPD: RPD_3575
RPE: RPE_1812
RPT: Rpal_4263
NWI: Nwi_2271
NHA: Nham_2684
OCA: OCAR_6673(hpnD)
VGO: GJW-30_1_02140(crtB_2)
MEX: Mext_1942
MDI: METDI2703
MCH: Mchl_2218
MET: M446_6349
MPO: Mpop_1833
MNO: Mnod_7144
MOR: MOC_5999(hpnD)
META: Y590_09030
MAQU: Maq22A_c25245(erg9)
BID: Bind_3154
MSL: Msil_3241
HDN: Hden_0475
RVA: Rvan_3019
MSC: BN69_1680
MTW: CQW49_11735(hpnD)
RBM: TEF_04820
ZMO: ZMO0870
ZMN: Za10_0422
ZMM: Zmob_0427
ZMB: ZZ6_0425
ZMI: ZCP4_0441
ZMC: A265_00436(crtM)
ZMR: A254_00436(crtM)
SPHM: G432_09190
GOX: GOX2258
GOH: B932_2744
GOY: GLS_c24010(hpnD)
ACR: Acry_0118
GDI: GDI1622
GDJ: Gdia_1827
GXY: GLX_17350
GXL: H845_3227
KEU: S101446_02251(crtB)
ASZ: ASN_2210
APOM: CPF11_06315(hpnD)
ATO: CIW82_01580(hpnD)
ABG: Asbog_02596(hpnD)
ROS: CTJ15_07700(hpnD)
MAG: amb1366
MAGX: XM1_1989
MAGN: WV31_17680
AZL: AZL_014580(crtB)
TMO: TMO_1552(crtB)
MAGQ: MGMAQ_1492
NAO: Y958_22680(hpnD)
 » show all
Taxonomy
Reference
1  [PMID:21746901]
  Authors
Niehaus TD, Okada S, Devarenne TP, Watt DS, Sviripa V, Chappell J
  Title
Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 108 (2011) 12260-5.
  Sequence
Reference
2  [PMID:26258173]
  Authors
Pan JJ, Solbiati JO, Ramamoorthy G, Hillerich BS, Seidel RD, Cronan JE, Almo SC, Poulter CD
  Title
Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes.
  Journal
ACS. Cent. Sci. 1 (2015) 77-82.
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.103
IUBMB Enzyme Nomenclature: 2.5.1.103
ExPASy - ENZYME nomenclature database: 2.5.1.103
BRENDA, the Enzyme Database: 2.5.1.103

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