KEGG   ENZYME: 2.5.1.106Help
Entry
EC 2.5.1.106                Enzyme                                 

Name
tryprostatin B synthase;
ftmPT1 (gene name);
brevianamide F prenyltransferase (ambiguous)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:brevianamide-F dimethylallyl-C-2-transferase
Reaction(IUBMB)
dimethylallyl diphosphate + brevianamide F = diphosphate + tryprostatin B [RN:R10340]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
brevianamide F [CPD:C20563]
Product
diphosphate [CPD:C00013];
tryprostatin B [CPD:C20512]
Comment
The enzyme from the fungus Aspergillus fumigatus can also prenylate other tryptophan-containing cyclic dipeptides. Prenylation occurs mainly at C-2 [1], but also at C-3 [2]. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, cyclotryprostatins, spirotryprostatins, fumitremorgins and verruculogen.
History
EC 2.5.1.106 created 2013
Pathway
Staurosporine biosynthesis
Biosynthesis of antibiotics
Orthology
K14132  
tryprostatin B synthase
Genes
AFM: 
NFI: 
Taxonomy
Reference
1  [PMID:16000710]
  Authors
Grundmann A, Li SM
  Title
Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatus.
  Journal
Microbiology. 151 (2005) 2199-207.
  Sequence
Reference
2  [PMID:23090579]
  Authors
Wollinsky B, Ludwig L, Xie X, Li SM
  Title
Breaking the regioselectivity of indole prenyltransferases: identification of regular C3-prenylated hexahydropyrrolo[2,3-b]indoles as side products of the regular C2-prenyltransferase FtmPT1.
  Journal
Org. Biomol. Chem. 10 (2012) 9262-70.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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