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Entry
EC 2.5.1.107                Enzyme                                 

Name
verruculogen prenyltransferase;
FtmPT3
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:verruculogen dimethylallyl-O-transferase
Reaction(IUBMB)
dimethylallyl diphosphate + verruculogen = diphosphate + fumitremorgin A [RN:R10341]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
verruculogen [CPD:C20045]
Product
diphosphate [CPD:C00013];
fumitremorgin A [CPD:C20564]
Comment
Found in a number of fungi. Catalyses the last step in the biosynthetic pathway of the indole alkaloid fumitremorgin A. The enzyme from the fungus Neosartorya fischeri is also active with fumitremorgin B and 12alpha,13alpha-dihydroxyfumitremorgin C.
History
EC 2.5.1.107 created 2013
Pathway
Staurosporine biosynthesis
Biosynthesis of antibiotics
Orthology
K18279  
verruculogen prenyltransferase
Genes
NFI: 
Taxonomy
Reference
1  [PMID:23109474]
  Authors
Mundt K, Wollinsky B, Ruan HL, Zhu T, Li SM
  Title
Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches.
  Journal
Chembiochem. 13 (2012) 2583-92.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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