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Entry
EC 2.5.1.110                Enzyme                                 

Name
12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase;
ftmH (gene name);
FtmPT2
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:12alpha,13alpha-dihydroxyfumitremorgin C dimethylallyl-N-1-transferase
Reaction(IUBMB)
dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C = diphosphate + fumitremorgin B [RN:R10457]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
12alpha,13alpha-dihydroxyfumitremorgin C [CPD:C20605]
Product
diphosphate [CPD:C00013];
fumitremorgin B [CPD:C20630]
Comment
The enzyme from the fungus Aspergillus fumigatus also shows some activity with fumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.
History
EC 2.5.1.110 created 2013
Pathway
ec00404  Staurosporine biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K14134  12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
Genes
AFM: AFUA_8G00250
NFI: NFIA_093760
Taxonomy
Reference
1  [PMID:18683158]
  Authors
Grundmann A, Kuznetsova T, Afiyatullov SSh, Li SM
  Title
FtmPT2, an N-prenyltransferase from Aspergillus fumigatus, catalyses the last step in the biosynthesis of fumitremorgin B.
  Journal
Chembiochem. 9 (2008) 2059-63.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.110
IUBMB Enzyme Nomenclature: 2.5.1.110
ExPASy - ENZYME nomenclature database: 2.5.1.110
BRENDA, the Enzyme Database: 2.5.1.110

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