KEGG   ENZYME: 2.5.1.111Help
Entry
EC 2.5.1.111                Enzyme                                 

Name
4-hydroxyphenylpyruvate 3-dimethylallyltransferase;
CloQ;
4HPP dimethylallyltransferase;
NovQ
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl diphosphate:4-hydroxyphenylpyruvate 3-dimethylallyltransferase
Reaction(IUBMB)
dimethylallyl diphosphate + 4-hydroxyphenylpyruvate = diphosphate + 3-dimethylallyl-4-hydroxyphenylpyruvate [RN:R06757]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
4-hydroxyphenylpyruvate [CPD:C01179]
Product
diphosphate [CPD:C00013];
3-dimethylallyl-4-hydroxyphenylpyruvate [CPD:C12456]
Comment
The enzyme is involved in the biosynthesis of the 3-dimethylallyl-4-hydroxyphenylpyruvate moiety of the aminocoumarin antibiotics clorobiocin and novobiocin [1].
History
EC 2.5.1.111 created 2013
Pathway
Novobiocin biosynthesis
Biosynthesis of antibiotics
Orthology
K12707  
4-hydroxyphenylpyruvate 3-dimethylallyltransferase
Reference
1  [PMID:12618544]
  Authors
Pojer F, Wemakor E, Kammerer B, Chen H, Walsh CT, Li SM, Heide L.
  Title
CloQ, a prenyltransferase involved in clorobiocin biosynthesis.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 2316-21.
  Sequence
Reference
2  [PMID:17077503]
  Authors
Keller S, Pojer F, Heide L, Lawson DM
  Title
Crystallization and preliminary X-ray analysis of the aromatic prenyltransferase  CloQ from the clorobiocin biosynthetic cluster of Streptomyces roseochromogenes.
  Journal
Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 62 (2006) 1153-5.
Reference
3  [PMID:20946900]
  Authors
Metzger U, Keller S, Stevenson CE, Heide L, Lawson DM
  Title
Structure and mechanism of the magnesium-independent aromatic prenyltransferase CloQ from the clorobiocin biosynthetic pathway.
  Journal
J. Mol. Biol. 404 (2010) 611-26.
  Sequence
Reference
4  [PMID:19557032]
  Authors
Ozaki T, Mishima S, Nishiyama M, Kuzuyama T
  Title
NovQ is a prenyltransferase capable of catalyzing the addition of a dimethylallyl group to both phenylpropanoids and flavonoids.
  Journal
J. Antibiot. (Tokyo). 62 (2009) 385-92.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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