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Entry
EC 2.5.1.112                Enzyme                                 

Name
adenylate dimethylallyltransferase (ADP/ATP-dependent);
cytokinin synthase (ambiguous);
isopentenyltransferase (ambiguous);
2-isopentenyl-diphosphate:ADP/ATP Delta2-isopentenyltransferase;
adenylate isopentenyltransferase (ambiguous);
dimethylallyl diphosphate:ATP/ADP isopentenyltransferase: IPT
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:ADP/ATP dimethylallyltransferase
Reaction(IUBMB)
(1) dimethylallyl diphosphate + ADP = diphosphate + N6-(dimethylallyl)adenosine 5'-diphosphate [RN:R08052];
(2) dimethylallyl diphosphate + ATP = diphosphate + N6-(dimethylallyl)adenosine 5'-triphosphate [RN:R08051]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
ADP [CPD:C00008];
ATP [CPD:C00002]
Product
diphosphate [CPD:C00013];
N6-(dimethylallyl)adenosine 5'-diphosphate [CPD:C16426];
N6-(dimethylallyl)adenosine 5'-triphosphate [CPD:C16424]
Comment
Involved in the biosynthesis of cytokinins in plants. The IPT4 isoform from the plant Arabidopsis thaliana is specific for ADP and ATP [1]. Other isoforms, such as IPT1 from Arabidopsis thaliana [1,2] and the enzyme from the common hop, Humulus lupulus [3], also have a lower activity with AMP (cf. EC 2.5.1.27, adenylate dimethylallyltransferase).
History
EC 2.5.1.112 created 2013
Pathway
Zeatin biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K10760  
adenylate dimethylallyltransferase (cytokinin synthase)
Genes
ATH: 
AT1G25410(IPT6) AT1G68460(IPT1) AT3G19160(IPT8) AT3G23630(IPT7) AT3G63110(IPT3) AT4G24650(IPT4) AT5G19040(IPT5)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0154359.1(Lj0g3v0154359.1) Lj0g3v0314119.1(Lj0g3v0314119.1) Lj0g3v0314129.1(Lj0g3v0314129.1) Lj4g3v2400530.1(Lj4g3v2400530.1) Lj5g3v0962690.1(Lj5g3v0962690.1) Lj5g3v2183860.1(Lj5g3v2183860.1)
LANG: 
FVE: 
PPER: 
PMUM: 
MDM: 
103402691(IPT1b) 103403839(IPT5b) 103432442(IPT3a) 103436938(IPT7a) 103437073 103449027(IPT3b) 103451645(IPT1a) 103453066(IPT5a)
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0004s15810g(POPTRDRAFT_556436) POPTR_0008s033302(POPTRDRAFT_563685) POPTR_0008s12060g(POPTRDRAFT_564538) POPTR_0008s20650g(POPTRDRAFT_766811) POPTR_0010s03150g(POPTRDRAFT_768739) POPTR_0010s13370g(POPTRDRAFT_566611) POPTR_0014s13540g(POPTRDRAFT_246143)
VVI: 
SLY: 
SPEN: 
SOT: 
INI: 
SIND: 
BVG: 
NNU: 
OSA: 
107276332(OsIPT5) 107277295(OsIPT3) 107278247(OsIPT8) 4332870(OsIPT2) 4334529(OsIPT4) 4339535(OsIPT7)
DOSA: 
Os01t0688300-00(Os01g0688300) Os03t0356900-01(Os03g0356900) Os03t0358900-00(Os03g0358900) Os03t0810100-01(Os03g0810100) Os05t0311801-00(Os05g0311801) Os05t0551700-01(Os05g0551700) Os07t0190150-00(Os07g0190150) Os07t0211700-00(Os07g0211700)
OBR: 
BDI: 
ATS: 
SBI: 
SORBI_01g003950(SORBIDRAFT_01g003950) SORBI_02g006400(SORBIDRAFT_02g006400) SORBI_03g014490(SORBIDRAFT_03g014490) SORBI_03g031570(SORBIDRAFT_03g031570) SORBI_06g014810(SORBIDRAFT_06g014810) SORBI_09g027683(SORBIDRAFT_09g027683)
ZMA: 
100158226(IPT5) 100158230(IPT4) 103630695(GRMZM2G025429) 103636191(GRMZM2G393014) 103644233(GRMZM2G116878) 103646537(GRMZM2G084462) 103649047(GRMZM2G018046) 103651327 103651988(IPT7)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
ZTR: 
 » show all
Taxonomy
Reference
1  [PMID:11479373]
  Authors
Kakimoto T.
  Title
Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.
  Journal
Plant. Cell. Physiol. 42 (2001) 677-85.
  Sequence
Reference
2  [PMID:11313355]
  Authors
Takei K, Sakakibara H, Sugiyama T
  Title
Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.
  Journal
J. Biol. Chem. 276 (2001) 26405-10.
  Sequence
Reference
3  [PMID:15381407]
  Authors
Sakano Y, Okada Y, Matsunaga A, Suwama T, Kaneko T, Ito K, Noguchi H, Abe I
  Title
Molecular cloning, expression, and characterization of adenylate isopentenyltransferase from hop (Humulus lupulus L.).
  Journal
Phytochemistry. 65 (2004) 2439-46.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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