KEGG   ENZYME: 2.5.1.112Help
Entry
EC 2.5.1.112                Enzyme                                 

Name
adenylate dimethylallyltransferase (ADP/ATP-dependent);
cytokinin synthase (ambiguous);
isopentenyltransferase (ambiguous);
2-isopentenyl-diphosphate:ADP/ATP Delta2-isopentenyltransferase;
adenylate isopentenyltransferase (ambiguous);
dimethylallyl diphosphate:ATP/ADP isopentenyltransferase: IPT
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:ADP/ATP dimethylallyltransferase
Reaction(IUBMB)
(1) dimethylallyl diphosphate + ADP = diphosphate + N6-(dimethylallyl)adenosine 5'-diphosphate [RN:R08052];
(2) dimethylallyl diphosphate + ATP = diphosphate + N6-(dimethylallyl)adenosine 5'-triphosphate [RN:R08051]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
ADP [CPD:C00008];
ATP [CPD:C00002]
Product
diphosphate [CPD:C00013];
N6-(dimethylallyl)adenosine 5'-diphosphate [CPD:C16426];
N6-(dimethylallyl)adenosine 5'-triphosphate [CPD:C16424]
Comment
Involved in the biosynthesis of cytokinins in plants. The IPT4 isoform from the plant Arabidopsis thaliana is specific for ADP and ATP [1]. Other isoforms, such as IPT1 from Arabidopsis thaliana [1,2] and the enzyme from the common hop, Humulus lupulus [3], also have a lower activity with AMP (cf. EC 2.5.1.27, adenylate dimethylallyltransferase).
History
EC 2.5.1.112 created 2013
Pathway
Zeatin biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Reference
1  [PMID:11479373]
  Authors
Kakimoto T.
  Title
Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.
  Journal
Plant. Cell. Physiol. 42 (2001) 677-85.
  Sequence
Reference
2  [PMID:11313355]
  Authors
Takei K, Sakakibara H, Sugiyama T
  Title
Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.
  Journal
J. Biol. Chem. 276 (2001) 26405-10.
  Sequence
Reference
3  [PMID:15381407]
  Authors
Sakano Y, Okada Y, Matsunaga A, Suwama T, Kaneko T, Ito K, Noguchi H, Abe I
  Title
Molecular cloning, expression, and characterization of adenylate isopentenyltransferase from hop (Humulus lupulus L.).
  Journal
Phytochemistry. 65 (2004) 2439-46.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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