KEGG   ENZYME: 2.5.1.115Help
Entry
EC 2.5.1.115                Enzyme                                 

Name
homogentisate phytyltransferase;
HPT;
VTE2 (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
phytyl diphosphate:homogentisate phytyltransferase
Reaction(IUBMB)
phytyl diphosphate + homogentisate = diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2 [RN:R07500]
Reaction(KEGG)
Substrate
phytyl diphosphate [CPD:C05427];
homogentisate [CPD:C00544]
Product
diphosphate [CPD:C00013];
2-methyl-6-phytylbenzene-1,4-diol [CPD:C15882];
CO2 [CPD:C00011]
Comment
Requires Mg2+ for activity [3]. Involved in the biosynthesis of the vitamin E tocopherols. While the enzyme from the cyanobacterium Synechocystis PCC 6803 has an appreciable activity with geranylgeranyl diphosphate (EC 2.5.1.116, homogentisate geranylgeranyltransferase), the enzyme from the plant Arabidopsis thaliana has only a low activity with that substrate [1,3,4].
History
EC 2.5.1.115 created 2014
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K09833  
homogentisate phytyltransferase / homogentisate geranylgeranyltransferase
Genes
ATH: 
AT2G18950(HPT1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0082139.1(Lj0g3v0082139.1) Lj0g3v0207399.1(Lj0g3v0207399.1) Lj0g3v0207399.2(Lj0g3v0207399.2) Lj0g3v0271809.1(Lj0g3v0271809.1) Lj0g3v0318259.1(Lj0g3v0318259.1) Lj0g3v0320339.1(Lj0g3v0320339.1) Lj0g3v0320339.2(Lj0g3v0320339.2) Lj0g3v0361429.2(Lj0g3v0361429.2) Lj2g3v3132450.1(Lj2g3v3132450.1) Lj2g3v3133590.1(Lj2g3v3133590.1) Lj4g3v2120440.1(Lj4g3v2120440.1) Lj6g3v2116900.1(Lj6g3v2116900.1)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0006s17980g POPTR_0018s02270g(POPTRDRAFT_261255) POPTR_0018s09790g(POPTRDRAFT_578578)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
4341663(HGGT) 4341727(HPT1)
DOSA: 
Os06t0658900-01(Os06g0658900)
OBR: 
BDI: 
ATS: 
SBI: 
SORBI_10g025475(SORBIDRAFT_10g025475) SORBI_10g026190(SORBIDRAFT_10g026190)
ZMA: 
100192568(GRMZM2G410644) 103638712(GRMZM2G173358) 103651727 732789(VTE2-1)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
SMIN: 
v1.2.025201.t1(symbB.v1.2.025201.t1)
PTI: 
AAF: 
EHX: 
GTT: 
SYN: 
SYZ: 
SYY: 
SYT: 
SYS: 
SYQ: 
SYJ: 
SYP: 
CYA: 
CYB: 
SYNE: 
SYNP: 
DSL: 
CMP: 
LEP: 
LEN: 
LET: 
PSEU: 
AMR: 
MAR: 
MPK: 
HAO: 
GLP: 
CYT: 
CYP: 
CYC: 
CYN: 
CYH: 
CYJ: 
TER: 
MIC: 
ARP: 
GEI: 
OAC: 
ONI: 
MPRO: 
CEP: 
GVI: 
gll0283(ubiA)
GLJ: 
GKIL_2663(ubiA)
ANA: 
NPU: 
NOS: 
NOP: 
NON: 
AVA: 
ANB: 
ACY: 
AWA: 
NAZ: 
CSG: 
CALO: 
CALT: 
CALH: 
RIV: 
FIS: 
CTHE: 
PLP: 
SCS: 
CAU: 
Caur_3427(ubiA)
CAG: 
CHL: 
 » show all
Taxonomy
Reference
1  [PMID:11706191]
  Authors
Collakova E, DellaPenna D
  Title
Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis.
  Journal
Plant. Physiol. 127 (2001) 1113-24.
  Sequence
[syn:slr1736][ath:AT2G18950]
Reference
2  [PMID:12011362]
  Authors
Savidge B, Weiss JD, Wong YH, Lassner MW, Mitsky TA, Shewmaker CK, Post-Beittenmiller D, Valentin HE
  Title
Isolation and characterization of homogentisate phytyltransferase genes from Synechocystis sp. PCC 6803 and Arabidopsis.
  Journal
Plant. Physiol. 129 (2002) 321-32.
  Sequence
[syn:slr1736][ath:AT2G18950]
Reference
3  [PMID:16989822]
  Authors
Sadre R, Gruber J, Frentzen M.
  Title
Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis.
  Journal
FEBS. Lett. 580 (2006) 5357-62.
  Sequence
[ath:AT2G18950]
Reference
4  [PMID:21223386]
  Authors
Yang W, Cahoon RE, Hunter SC, Zhang C, Han J, Borgschulte T, Cahoon EB
  Title
Vitamin E biosynthesis: functional characterization of the monocot homogentisate  geranylgeranyl transferase.
  Journal
Plant. J. 65 (2011) 206-17.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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