KEGG   ENZYME: 2.5.1.116Help
Entry
EC 2.5.1.116                Enzyme                                 

Name
homogentisate geranylgeranyltransferase;
HGGT;
slr1736 (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranylgeranyl diphosphate:homogentisate geranylgeranyltransferase
Reaction(IUBMB)
geranylgeranyl diphosphate + homogentisate = diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 [RN:R10708]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353];
homogentisate [CPD:C00544]
Product
diphosphate [CPD:C00013];
6-geranylgeranyl-2-methylbenzene-1,4-diol [CPD:C20737];
CO2 [CPD:C00011]
Comment
Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate [2].
History
EC 2.5.1.116 created 2014
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Biosynthesis of secondary metabolites
Orthology
K09833  
homogentisate phytyltransferase / homogentisate geranylgeranyltransferase
Genes
ATH: 
AT2G18950(HPT1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0082139.1(Lj0g3v0082139.1) Lj0g3v0207399.1(Lj0g3v0207399.1) Lj0g3v0207399.2(Lj0g3v0207399.2) Lj0g3v0271809.1(Lj0g3v0271809.1) Lj0g3v0318259.1(Lj0g3v0318259.1) Lj0g3v0320339.1(Lj0g3v0320339.1) Lj0g3v0320339.2(Lj0g3v0320339.2) Lj0g3v0361429.2(Lj0g3v0361429.2) Lj2g3v3132450.1(Lj2g3v3132450.1) Lj2g3v3133590.1(Lj2g3v3133590.1) Lj4g3v2120440.1(Lj4g3v2120440.1) Lj6g3v2116900.1(Lj6g3v2116900.1)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0006s17980g POPTR_0018s02270g(POPTRDRAFT_261255) POPTR_0018s09790g(POPTRDRAFT_578578)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
4341663(HGGT) 4341727(HPT1)
DOSA: 
Os06t0658900-01(Os06g0658900)
OBR: 
BDI: 
ATS: 
SBI: 
SORBI_10g025475(SORBIDRAFT_10g025475) SORBI_10g026190(SORBIDRAFT_10g026190)
ZMA: 
100192568(GRMZM2G410644) 103638712(GRMZM2G173358) 103651727 732789(VTE2-1)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
SMIN: 
v1.2.025201.t1(symbB.v1.2.025201.t1)
PTI: 
AAF: 
EHX: 
GTT: 
SYN: 
SYZ: 
SYY: 
SYT: 
SYS: 
SYQ: 
SYJ: 
SYP: 
CYA: 
CYB: 
SYNE: 
SYNP: 
DSL: 
CMP: 
LEP: 
LEN: 
LET: 
PSEU: 
AMR: 
MAR: 
MPK: 
HAO: 
GLP: 
CYT: 
CYP: 
CYC: 
CYN: 
CYH: 
CYJ: 
TER: 
MIC: 
ARP: 
GEI: 
OAC: 
ONI: 
CEP: 
GVI: 
gll0283(ubiA)
GLJ: 
GKIL_2663(ubiA)
ANA: 
NPU: 
NOS: 
NOP: 
NON: 
AVA: 
ANB: 
ACY: 
AWA: 
NAZ: 
CSG: 
CALO: 
CALT: 
CALH: 
RIV: 
FIS: 
CTHE: 
PLP: 
SCS: 
CAU: 
Caur_3427(ubiA)
CAG: 
CHL: 
 » show all
Taxonomy
Reference
1  [PMID:11706191]
  Authors
Collakova E, DellaPenna D
  Title
Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis.
  Journal
Plant. Physiol. 127 (2001) 1113-24.
  Sequence
[syn:slr1736][ath:AT2G18950]
Reference
2  [PMID:12897790]
  Authors
Cahoon EB, Hall SE, Ripp KG, Ganzke TS, Hitz WD, Coughlan SJ
  Title
Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content.
  Journal
Nat. Biotechnol. 21 (2003) 1082-7.
  Sequence
[osa:4341663]
Reference
3  [PMID:21223386]
  Authors
Yang W, Cahoon RE, Hunter SC, Zhang C, Han J, Borgschulte T, Cahoon EB
  Title
Vitamin E biosynthesis: functional characterization of the monocot homogentisate  geranylgeranyl transferase.
  Journal
Plant. J. 65 (2011) 206-17.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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