KEGG   ENZYME: 2.5.1.117Help
Entry
EC 2.5.1.117                Enzyme                                 

Name
homogentisate solanesyltransferase;
HST;
PDS2 (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
all-trans-nonaprenyl diphosphate:homogentisate nonaprenyltransferase
Reaction(IUBMB)
all-trans-nonaprenyl diphosphate + homogentisate = diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 [RN:R08782]
Reaction(KEGG)
Substrate
all-trans-nonaprenyl diphosphate [CPD:C04145];
homogentisate [CPD:C00544]
Product
diphosphate [CPD:C00013];
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol [CPD:C17570];
CO2 [CPD:C00011]
Comment
Requires Mg2+ for activity. Part of the biosynthesis pathway of plastoquinol-9. The enzymes purified from the plant Arabidopsis thaliana and the alga Chlamydomonas reinhardtii are also active in vitro with unsaturated C10-C20 prenyl diphosphates, producing main products that are not decarboxylated [2].
History
EC 2.5.1.117 created 2014
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Orthology
K12501  
homogentisate solanesyltransferase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0006s21200g(POPTRDRAFT_819322)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
4329918(OJ1058_F07.14) 4335190 4343702(HPT2) 4351674
DOSA: 
Os02t0605500-01(Os02g0605500) Os04t0217900-01(Os04g0217900) Os04t0218900-01(Os04g0218900) Os07t0576000-01(Os07g0576000) Os12t0181300-00(Os12g0181300)
OBR: 
BDI: 
SBI: 
SORBI_02g037370(SORBIDRAFT_02g037370) SORBI_04g025460(SORBIDRAFT_04g025460)
ZMA: 
100192987(GRMZM2G001097) 100194079 100280305(cl627_1)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
CCP: 
PTI: 
TPS: 
EHX: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:16989822]
  Authors
Sadre R, Gruber J, Frentzen M.
  Title
Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis.
  Journal
FEBS. Lett. 580 (2006) 5357-62.
  Sequence
Reference
2  [PMID:20400515]
  Authors
Sadre R, Frentzen M, Saeed M, Hawkes T
  Title
Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis.
  Journal
J. Biol. Chem. 285 (2010) 18191-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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