KEGG   ENZYME: 2.5.1.118Help
Entry
EC 2.5.1.118                Enzyme                                 

Name
beta-(isoxazolin-5-on-2-yl)-L-alanine synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
O-acetyl-L-serine:isoxazolin-5-one 2-(2-amino-2-carboxyethyl)transferase
Reaction(IUBMB)
O-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate [RN:R10839]
Reaction(KEGG)
Substrate
O-acetyl-L-serine [CPD:C00979];
isoxazolin-5-one [CPD:C20891]
Product
3-(5-oxoisoxazolin-2-yl)-L-alanine [CPD:C20892];
acetate [CPD:C00033]
Comment
The enzyme from the plants Lathyrus odoratus (sweet pea) and L. sativus (grass pea) also forms 3-(5-oxoisoxazolin-4-yl)-L-alanine in vitro (cf. EC 2.5.1.119). However, only 3-(5-oxoisoxazolin-2-yl)-L-alanine is formed in vivo. 3-(5-oxoisoxazolin-2-yl)-L-alanine is the biosynthetic precursor of the neurotoxin N3-oxalyl-L-2,3-diaminopropanoic acid, the cause of lathyrism. Closely related and possibly identical to EC 2.5.1.47, cysteine synthase, and EC 2.5.1.51, beta-pyrazolylalanine synthase.
History
EC 2.5.1.118 created 2014
Reference
1  [PMID:8889043]
  Authors
Ikegami F, Kamiya M, Kuo YH, Lambein F, Murakoshi I
  Title
Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species.
  Journal
Biol. Pharm. Bull. 19 (1996) 1214-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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