KEGG   ENZYME: 2.5.1.119Help
Entry
EC 2.5.1.119                Enzyme                                 

Name
beta-(isoxazolin-5-on-4-yl)-L-alanine synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
O-acetyl-L-serine:isoxazolin-5-one 4-(2-amino-2-carboxyethyl)transferase
Reaction(IUBMB)
O-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate [RN:R10840]
Reaction(KEGG)
Substrate
O-acetyl-L-serine [CPD:C00979];
isoxazolin-5-one [CPD:C20891]
Product
3-(5-oxoisoxazolin-4-yl)-L-alanine [CPD:C20893];
acetate [CPD:C00033]
Comment
3-(5-Oxoisoxazolin-4-yl)-L-alanine is an antifungal antibiotic produced by the bacterium Streptomyces platensis. The enzymes from the plants Lathyrus odoratus (sweet pea), L. sativus (grass pea) and Citrullus vulgaris (watermelon) that catalyse EC 2.5.1.118 (beta-(isoxazolin-5-on-2-yl)-L-alanine synthase) also catalyse this reaction in vitro, but not in vivo. Closely related and possibly identical to EC 2.5.1.47, cysteine synthase, and EC 2.5.1.51, beta-pyrazolylalanine synthase.
History
EC 2.5.1.119 created 2014
Reference
1  [PMID:8889043]
  Authors
Ikegami F, Kamiya M, Kuo YH, Lambein F, Murakoshi I
  Title
Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species.
  Journal
Biol. Pharm. Bull. 19 (1996) 1214-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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