KEGG   ENZYME: 2.5.1.120Help
Entry
EC 2.5.1.120                Enzyme                                 

Name
aminodeoxyfutalosine synthase;
MqnE;
AFL synthase;
aminofutalosine synthase;
S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (bicarbonate-hydrolysing, 6-amino-6-deoxyfutalosine-forming)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (HCO3--hydrolysing, 6-amino-6-deoxyfutalosine-forming)
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O = 6-amino-6-deoxyfutalosine + L-methionine + HCO3- [RN:R10667]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3-[(1-carboxyvinyl)oxy]benzoate [CPD:C20772];
H2O [CPD:C00001]
Product
6-amino-6-deoxyfutalosine [CPD:C20773];
L-methionine [CPD:C00073];
HCO3- [CPD:C00288]
Comment
This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the transferred adenosyl group. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
History
EC 2.5.1.120 created 2014
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K18285  aminodeoxyfutalosine synthase
Genes
HPY: HP0654
HEO: C694_03380
HPJ: jhp_0599
HPA: HPAG1_0639
HPS: HPSH_03585
HHP: HPSH112_03740
HHQ: HPSH169_03355
HHR: HPSH417_03165
HPG: HPG27_616
HPP: HPP12_0667
HPL: HPB8_857
HPZ: HPKB_0690
HPD: KHP_0667
HEY: MWE_0854
HPYR: K747_07365
HPYI: K750_05585
HPYU: K751_04110
HPYM: K749_02000
HEB: U063_0958
HEZ: U064_0962
HHE: HH_1021
HAC: Hac_0839
HMS: HMU06060
HCE: HCW_05760
HCM: HCD_05315
HCP: HCN_0074
WSU: WS2177
SUA: Saut_1516
SULR: B649_03315
CJE: Cj1368
CJU: C8J_1287
CJI: CJSA_1302
CJM: CJM1_1328
CJS: CJS3_1466
CJEJ: N564_01364
CJEU: N565_01404
CJEN: N755_01401
CJEI: N135_01456
CJER: H730_07805
CJY: QZ67_01505(mqnE_2)
CJQ: UC78_1315(mqnE_2)
CJR: CJE1560
CFZ: CSG_2310
CLA: Cla_0427
CCQ: N149_1332
CCF: YSQ_02015
CCY: YSS_07410
CCOI: YSU_02050
CCOF: VC76_06860(mqnE_2)
CCOO: ATE51_00826(mqnE_1)
CIS: CINS_0406
CVO: CVOL_0417
CPEL: CPEL_0436
CGRA: CGRAC_1021
CURE: CUREO_1051
CHYO: CHH_0511
CSPF: CSF_0597
CCUN: CCUN_1423
CLX: CLAN_0672
ABU: Abu_0251
ABT: ABED_0234
ARC: ABLL_0385
SDL: Sdel_1686
SMUL: SMUL_2362
SHAL: SHALO_2108
SULJ: SJPD1_2127
NIS: NIS_0648
SUN: SUN_0538
NAM: NAMH_1275
GSU: GSU0441(mqnC-2)
GSK: KN400_0416(mqnC-2)
GME: Gmet_3391(mqnC-2)
GUR: Gura_4284
GLO: Glov_0625
GBM: Gbem_0234(mqnC-2)
GEO: Geob_0418(mqnC-2)
GEM: GM21_0218
GEB: GM18_0263
PCA: Pcar_0319(mqnC-2)
PPD: Ppro_3578
DES: DSOUD_0278(mqnC-2)
DEU: DBW_0510
DVU: DVU2756
DVL: Dvul_0551
DVM: DvMF_1188
DDE: Dde_0798
DDS: Ddes_1279
DMA: DMR_08720
DGG: DGI_2623
DAS: Daes_2223
DPI: BN4_20498
PPRF: DPRO_3994(mqnE)
DBA: Dbac_2962
DRT: Dret_0149
DSF: UWK_02735
DOL: Dole_1271
DML: Dmul_31780(cofH)
DTO: TOL2_C34500(cofH)
ADE: Adeh_0372
SFU: Sfum_3089
DBR: Deba_2194
BHA: BH3411
BCL: ABC2933
BKW: BkAM31D_19845(mqnE_2)
BBEV: BBEV_0644
BSE: Bsel_1178
PPY: PPE_03905
PPO: PPM_4103(M1_4511)
PPOL: X809_36635
PPOY: RE92_16725
PMW: B2K_05750
PLV: ERIC2_c29720(cofH2)
PSAB: PSAB_19705
PRI: PRIO_5647
PSWU: SY83_00115
ASOC: CB4_01045(mqnE_1)
STH: STH817
SWO: Swol_1157
SLP: Slip_1167
DRM: Dred_2195
DAE: Dtox_1643
PTH: PTH_0209(ThiH)
DAU: Daud_1089
SGY: Sgly_2856
HMO: HM1_1947
CHY: CHY_1806
MTA: Moth_1846
ADG: Adeg_1450
MHG: MHY_27660
SCO: SCO4494(SCD35.01)
SMA: SAVERM_4813(cofH1)
SGR: SGR_4206
SGB: WQO_14525
SCT: SCAT_3453
SFA: Sfla_3609
SBH: SBI_06076
SHY: SHJG_5673
SVE: SVEN_3124
SALB: XNR_3569
STRP: F750_3111
SFI: SFUL_2949
SALU: DC74_3919
SALL: SAZ_20730
STRE: GZL_04979
SLD: T261_4549
STRM: M444_20155
SAMB: SAM23877_4308(mqnE)
SPRI: SPRI_3302
SRW: TUE45_05083(mqnE_2)
SLE: sle_31070(sle_31070)
SRN: A4G23_03229(mqnE_2)
STRD: NI25_16410
SLAU: SLA_3191
SALJ: SMD11_3743
SLX: SLAV_21775(mqnE3)
KSK: KSE_33060
FAL: FRAAL1010
ACE: Acel_0259
SAQ: Sare_4505
MIL: ML5_0333
AMS: AMIS_2050
ASE: ACPL_421
ACTN: L083_0397
AFS: AFR_01470
CAI: Caci_8066
SNA: Snas_0587
HAU: Haur_2163
DRA: DR_0366
DGE: Dgeo_2097
TRA: Trad_0908
TTH: TT_C0452
TTJ: TTHA0804
TAQ: TO73_1465
MRB: Mrub_0787
XII: AMD24_00441(mqnE_2)
MIN: Minf_1916(thiH)
RBA: RB2748
PSL: Psta_0917
PIR: VN12_23070(mqnE_2)
PLM: Plim_0097
PLS: VT03_28800(mqnE_1)
PLH: VT85_20755(mqnE_2)
TTF: THTE_2437
GES: VT84_02115(mqnE_1)
IPA: Isop_1895
SACI: Sinac_1135
PBOR: BSF38_04469(mqnE)
ACA: ACP_0913
SUS: Acid_1309
FSC: FSU_2870
GAU: GAU_1634
GBA: J421_3267
BACC: BRDCF_p1368(cofH)
AFD: Alfi_1359
CPI: Cpin_4713
FLN: FLA_3666
SGN: SGRA_3725
PHE: Phep_1880
MUC: MuYL_2738
MGOT: MgSA37_02948(mqnE_2)
AAE: aq_648
HTH: HTH_1238
TAL: Thal_0761
TTK: TST_1168
CABY: Cabys_3286(mqnE)
MOX: DAMO_1584
GAC: GACE_1763
GAH: GAH_00871
NMR: Nmar_0742
NCT: NMSP_0686(cofH_1)
TAA: NMY3_02629(mqnE_2)
NBV: T478_0614
NDV: NDEV_1291
 » show all
Taxonomy
Reference
1  [PMID:24083939]
  Authors
Mahanta N, Fedoseyenko D, Dairi T, Begley TP
  Title
Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical  SAM enzyme.
  Journal
J. Am. Chem. Soc. 135 (2013) 15318-21.
  Sequence
[sco:SCO4494] [ttj:TTHA0804]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.120
IUBMB Enzyme Nomenclature: 2.5.1.120
ExPASy - ENZYME nomenclature database: 2.5.1.120
BRENDA, the Enzyme Database: 2.5.1.120

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