KEGG   ENZYME: 2.5.1.124Help
Entry
EC 2.5.1.124                Enzyme                                 

Name
6-linalyl-2-O,3-dimethylflaviolin synthase;
Fur7;
6-(3,7-dimethylocta-1,6-dien-3-yl)-5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranyl diphosphate:2-O-methyl-3-methylflaviolin geranyltransferase (6-linalyl-2-O,3-dimethylflaviolin-forming)
Reaction(IUBMB)
geranyl diphosphate + 2-O,3-dimethylflaviolin = diphosphate + 6-linalyl-2-O,3-dimethylflaviolin [RN:R11086]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
2-O,3-dimethylflaviolin [CPD:C21001]
Product
diphosphate [CPD:C00013];
6-linalyl-2-O,3-dimethylflaviolin [CPD:C21002]
Comment
The enzyme is involved in biosynthesis of the polyketide-isoprenoid furaquinocin D in the bacterium Streptomyces sp. KO-3988. It catalyses the transfer of a geranyl group to 2-O,3-dimethylflaviolin to yield 6-linalyl-2-O,3-dimethylflaviolin and 7-O-geranyl-2-O,3-dimethylflaviolin (cf. EC 2.5.1.125, 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase) in a 10:1 ratio.
History
EC 2.5.1.124 created 2014
Reference
1  [PMID:20937800]
  Authors
Kumano T, Tomita T, Nishiyama M, Kuzuyama T
  Title
Functional characterization of the promiscuous prenyltransferase responsible for  furaquinocin biosynthesis: identification of a physiological polyketide substrate and its prenylated reaction products.
  Journal
J. Biol. Chem. 285 (2010) 39663-71.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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