KEGG   ENZYME: 2.5.1.127Help
Entry
EC 2.5.1.127                Enzyme                                 

Name
caldopentamine synthase;
long-chain polyamine synthase (ambiguous)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl 3-(methylthio)propylamine:norspermine 3-aminopropyltransferase
Reaction(IUBMB)
S-adenosyl 3-(methylthio)propylamine + norspermine = S-methyl-5'-thioadenosine + caldopentamine [RN:R11089]
Reaction(KEGG)
Substrate
S-adenosyl 3-(methylthio)propylamine [CPD:C01137];
norspermine [CPD:C21004]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
caldopentamine [CPD:C21100]
Comment
The enzyme, characterized from the thermophilic archaeon Hyperthermus butylicus, can also synthesize norspermine from norspermidine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.23, sym-norspermidine synthase and EC 2.5.1.126, norspermine synthase, this enzyme shows no activity with propane-1,3-diamine.
History
EC 2.5.1.127 created 2014
Reference
1  [PMID:19822146]
  Authors
Knott JM
  Title
Biosynthesis of long-chain polyamines by crenarchaeal polyamine synthases from Hyperthermus butylicus and Pyrobaculum aerophilum.
  Journal
FEBS. Lett. 583 (2009) 3519-24.
  Sequence
[hbu:Hbut_0057]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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