KEGG   ENZYME: 2.5.1.25Help
Entry
EC 2.5.1.25                 Enzyme                                 

Name
tRNA-uridine aminocarboxypropyltransferase;
S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:uridine47 in tRNAPhe 3-[(3S)-3-amino-3-carboxypropyl]transferase
Reaction(IUBMB)
S-adenosyl-L-methionine + uridine47 tRNAPhe = S-methyl-5'-thioadenosine + 3-[(3S)-3-amino-3-carboxypropyl]-uridine47 in tRNAPhe [RN:R03019]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
uridine47 tRNAPhe
Product
S-methyl-5'-thioadenosine [CPD:C00170];
3-[(3S)-3-amino-3-carboxypropyl]-uridine47 in tRNAPhe
Comment
The enzyme was studied in the bacterium Escherichia coli. The modification is found in the variable loop of the tRNA.
History
EC 2.5.1.25 created 1984, modified 2014
Reference
1  [PMID:4597321]
  Authors
Nishimura S, Taya Y, Kuchino Y, Oashi Z.
  Title
Enzymatic synthesis of 3-(3-amino-3-carboxypropyl)uridine in Escherichia coli phenylalanine transfer RNA: transfer of the 3-amino-acid-3-carboxypropyl group from S-adenosylmethionine.
  Journal
Biochem. Biophys. Res. Commun. 57 (1974) 702-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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