KEGG   ENZYME: 2.5.1.41Help
Entry
EC 2.5.1.41                 Enzyme                                 

Name
phosphoglycerol geranylgeranyltransferase;
glycerol phosphate geranylgeranyltransferase;
geranylgeranyl-transferase (ambiguous);
prenyltransferase (ambiguous);
(S)-3-O-geranylgeranylglyceryl phosphate synthase;
(S)-geranylgeranylglyceryl phosphate synthase;
GGGP synthase;
(S)-GGGP synthase;
GGGPS;
geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase;
geranylgeranyl diphosphate:sn-glycerol-1-phosphate geranylgeranyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate:sn-glycerol-1-phosphate geranylgeranyltransferase
Reaction(IUBMB)
geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate [RN:R04158]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353];
sn-glycerol 1-phosphate [CPD:C00623]
Product
diphosphate [CPD:C00013];
3-(O-geranylgeranyl)-sn-glycerol 1-phosphate [CPD:C04590]
Comment
This cytosolic enzyme catalyses the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria [2]. Requires Mg2+ for maximal activity [2]. It catalyses the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase) and EC 2.7.7.67 (CDP-archaeol synthase), which lead to the formation of CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [5].
History
EC 2.5.1.41 created 1992, modified 2009
Pathway
Glycerophospholipid metabolism
Orthology
K17104  
phosphoglycerol geranylgeranyltransferase
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MBA: 
MBY: 
MBW: 
MBAR: 
MMA: 
MMAZ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
MEMA: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MEZ: 
RCI: 
MTH: 
MMG: 
METC: 
MST: 
Msp_1291(pcrB)
MSI: 
MRU: 
MEB: 
MMIL: 
MEYE: 
MEL: 
MEW: 
METH: 
MFC: 
MFI: 
MFV: 
MKA: 
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
HAL: 
HSL: 
OE_1398R(pcrB1) OE_3699R(pcrB2)
HDL: 
HHB: 
Hhub_1410(pcrB)
HMA: 
rrnAC1650(pcrB)
HHI: 
HAH_2191(pcrB)
HHN: 
HAB: 
NPH: 
NP_1224A(pcrB)
NMO: 
Nmlp_2072(pcrB)
HUT: 
HTI: 
HMU: 
HJE: 
HSU: 
HSF: 
HWA: 
HQ_1269A(pcrB)
HWC: 
Hqrw_1298(pcrB)
HLA: 
HVO: 
HVO_0680(pcrB1) HVO_1086(pcrB2)
HME: 
HGI: 
HBO: 
HTU: 
NMG: 
HXA: 
NAT: 
NPE: 
NGE: 
HRU: 
NOU: 
SALI: 
HLR: 
TAC: 
PTO: 
FAC: 
TAR: 
MAX: 
MER: 
MEAR: 
MARC: 
PHO: 
PH1124(PH1124)
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TGAM_1175(gggPS)
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
TGY: 
THV: 
PPAC: 
ABI: 
ACF: 
APE: 
ACJ: 
SMR: 
SHC: 
IHO: 
IIS: 
DKA: 
DMU: 
DFD: 
TAG: 
IAG: 
THG: 
HBU: 
PFM: 
PDL: 
SSO: 
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
AHO: 
PAI: 
PIS: 
PCL: 
PAS: 
PYR: 
POG: 
TNE: 
PYW: 
CMA: 
TUZ: 
TTN: 
VDI: 
VMO: 
TPE: 
THB: 
TCB: 
THF: 
ASC: 
CLG: 
FFO: 
NMR: 
NIR: 
NID: 
NIN: 
NKR: 
CSY: 
NGA: 
NVN: 
NEV: 
TAA: 
CSU: 
NBV: 
TAH: 
KCR: 
LOKI: 
BARC: 
BARB: 
HAH: 
AGW: 
 » show all
Taxonomy
Reference
1
  Authors
Zhang, D.-L., Daniels, L. and Poulter, C.D.
  Title
Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction.
  Journal
J. Am. Chem. Soc. 112 (1990) 1264-1265.
Reference
2  [PMID:8408023]
  Authors
Chen A, Zhang D, Poulter CD
  Title
(S)-geranylgeranylglyceryl phosphate synthase. Purification and characterization of the first pathway-specific enzyme in archaebacterial membrane lipid biosynthesis.
  Journal
J. Biol. Chem. 268 (1993) 21701-5.
  Sequence
Reference
3  [PMID:12801917]
  Authors
Nemoto N, Oshima T, Yamagishi A
  Title
Purification and characterization of geranylgeranylglyceryl phosphate synthase from a thermoacidophilic archaeon, Thermoplasma acidophilum.
  Journal
J. Biochem. 133 (2003) 651-7.
  Sequence
[tac:Ta0995]
Reference
4  [PMID:16377641]
  Authors
Payandeh J, Fujihashi M, Gillon W, Pai EF
  Title
The crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase reveals an ancient fold for an ancient enzyme.
  Journal
J. Biol. Chem. 281 (2006) 6070-8.
  Sequence
[afu:AF_0403]
Reference
5  [PMID:10960477]
  Authors
Morii H, Nishihara M, Koga Y
  Title
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus.
  Journal
J. Biol. Chem. 275 (2000) 36568-74.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
124650-69-7

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