KEGG   ENZYME: 2.5.1.42Help
Entry
EC 2.5.1.42                 Enzyme                                 

Name
geranylgeranylglycerol-phosphate geranylgeranyltransferase;
geranylgeranyloxyglycerol phosphate geranylgeranyltransferase;
geranylgeranyltransferase II;
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase;
DGGGP synthase;
DGGGPS;
geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranylgeranyl diphosphate:3-(O-geranylgeranyl)-sn-glycerol 1-phosphate geranylgeranyltransferase
Reaction(IUBMB)
geranylgeranyl diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate [RN:R04520]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353];
3-(O-geranylgeranyl)-sn-glycerol 1-phosphate [CPD:C04590]
Product
diphosphate [CPD:C00013];
2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
Comment
This enzyme is an integral-membrane protein that carries out the second prenyltransfer reaction involved in the formation of polar membrane lipids in Archaea. Requires a divalent metal cation, such as Mg2+ or Mn2+, for activity [2]. 4-Hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate and alpha-glycerophosphate cannot act as prenyl-acceptor substrates [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase), which, together with this enzyme, alkylates the hydroxy groups of glycerol 1-phosphate to yield unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 (CDP-archaeol synthase) to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [3]. Belongs in the UbiA prenyltransferase family [2].
History
EC 2.5.1.42 created 1992, modified 2009
Pathway
Glycerophospholipid metabolism
Orthology
K17105  
geranylgeranylglycerol-phosphate geranylgeranyltransferase
Genes
LFA: 
DOR: 
DMI: 
HMO: 
HM1_3117(ubiA)
SVL: 
SRC: 
SEN: 
ACTN: 
RXY: 
CYN: 
AMR: 
AM1_D0196(ubiA)
CTHE: 
PLP: 
RRS: 
CTE: 
CPH: 
CTS: 
IAL: 
IALB_0629(ubiA)
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MA_0961(ubiA)
MBA: 
MBY: 
MBW: 
MBAR: 
MMA: 
MMAZ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MEV: 
MZH: 
MPY: 
Mpsy_1283(ubiA) Mpsy_1441(ubiA2)
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
BN140_0748(ubiA1)
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MEZ: 
RCI: 
LRC477(ubiA-1) RCIX579(ubiA-2)
MTH: 
MMG: 
METC: 
MST: 
MSI: 
MRU: 
MEB: 
MMIL: 
MEYE: 
MEL: 
MEW: 
METH: 
MFC: 
MFI: 
MFV: 
MKA: 
MK0953(ubiA)
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
HAL: 
VNG0610G(ubiA)
HSL: 
OE_1921R(ubiA2)
HDL: 
HHB: 
NPH: 
NP_4470A(ubiA2)
NMO: 
Nmlp_2958(ubiA2)
HJE: 
HSU: 
HSF: 
HWA: 
HQ_1884A(ubiA2)
HWC: 
Hqrw_2024(ubiA2)
HLA: 
HVO: 
HVO_1436(hhoA)
HME: 
HFX_1501(ubiA)
HGI: 
HBO: 
HTU: 
NMG: 
HXA: 
NAT: 
NPE: 
NGE: 
HRU: 
NOU: 
SALI: 
HLR: 
TVO: 
PTO: 
FAC: 
TAR: 
MAX: 
MER: 
MEAR: 
MARC: 
PHO: 
PH0027(PH0027)
PAB: 
PAB0018(ubiA-like)
PFU: 
PFI: 
PFC_08765(ubiA)
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TSI: 
TBA: 
THE: 
GQS_05375(ubiA)
THA: 
THM: 
TLT: 
OCC_02582(ubiA)
THS: 
TNU: 
TEU: 
TEU_04265(ubiA)
TGY: 
THV: 
PPAC: 
PAP_00080(ubiA)
ABI: 
ACF: 
APE: 
ACJ: 
SMR: 
SHC: 
IHO: 
IIS: 
DKA: 
DMU: 
DFD: 
TAG: 
IAG: 
THG: 
HBU: 
PFM: 
PDL: 
SSO: 
SSO0583(ubiA-2)
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
AHO: 
PAI: 
PIS: 
PCL: 
PAS: 
PYR: 
POG: 
TNE: 
PYW: 
CMA: 
TUZ: 
TTN: 
TTX_1501(ubiA)
VDI: 
VMO: 
TPE: 
THB: 
TCB: 
ASC: 
CLG: 
FFO: 
NGA: 
NEV: 
CSU: 
KCR: 
LOKI: 
BARB: 
AGW: 
 » show all
Taxonomy
Reference
1
  Authors
Zhang, D.-L., Daniels, L. and Poulter, C.D.
  Title
Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction.
  Journal
J. Am. Chem. Soc. 112 (1990) 1264-1265.
Reference
2  [PMID:15356000]
  Authors
Hemmi H, Shibuya K, Takahashi Y, Nakayama T, Nishino T
  Title
(S)-2,3-Di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids.
  Journal
J. Biol. Chem. 279 (2004) 50197-203.
  Sequence
[sso:SSO0583]
Reference
3  [PMID:10960477]
  Authors
Morii H, Nishihara M, Koga Y
  Title
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus.
  Journal
J. Biol. Chem. 275 (2000) 36568-74.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
124650-68-6

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