KEGG   ENZYME: 2.5.1.53Help
Entry
EC 2.5.1.53                 Enzyme                                 

Name
uracilylalanine synthase;
O3-acetyl-L-serine acetate-lyase (adding uracil);
isowillardiine synthase;
willardiine synthase;
3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase;
O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase
Reaction(IUBMB)
O-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate [RN:R03131]
Reaction(KEGG)
Substrate
O-acetyl-L-serine [CPD:C00979];
uracil [CPD:C00106]
Product
3-(uracil-1-yl)-L-alanine [CPD:C03584];
acetate [CPD:C00033]
Comment
The enzyme produces the non-proteinogenic amino acid L-willardiine, which is naturally found in the plants Acacia willardiana, Mimosa pigra, and Pisum sativum (pea). The enzyme from Pisum species also produces L-isowillardiine. Not identical with EC 2.5.1.47 cysteine synthase.
History
EC 2.5.1.53 created 1990 as EC 4.2.99.16, transferred 2002 to EC 2.5.1.53
Reference
1
  Authors
Ahmmad, M.A.S., Maskall, C.S. and Brown, E.G.
  Title
Partial-purification and properties of willardiine and synthase activity from Pisum sativum.
  Journal
Phytochemistry 23 (1984) 265-270.
Reference
2
  Authors
Ikegami, F., Kaneko, M., Lambein, F., Kuo, Y.-H. and Murakoshi, I.
  Title
Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum.
  Journal
Phytochemistry 26 (1987) 2699-2704.
Reference
3
  Authors
Murakoshi, I., Ikegami, F., Ookawa, N., Ariki, T., Haginiwa, J., Kuo, Y.-H. and Lambein, F.
  Title
Biosynthesis of the uracilylalanines willardiine and isowillardiine in higher plants.
  Journal
Phytochemistry 17 (1978) 1571-1576.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
113573-73-2

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