KEGG   ENZYME: 2.5.1.57Help
Entry
EC 2.5.1.57                 Enzyme                                 
Name
N-acylneuraminate-9-phosphate synthase;
N-acetylneuraminate 9-phosphate lyase;
N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase;
N-acetylneuraminate 9-phosphate synthetase;
N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating);
sialic acid 9-phosphate synthetase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate [RN:R02769]
Reaction(KEGG)
Substrate
phosphoenolpyruvate [CPD:C00074];
N-acyl-D-mannosamine 6-phosphate [CPD:C00686];
H2O [CPD:C00001]
Product
N-acylneuraminate 9-phosphate [CPD:C01200];
phosphate [CPD:C00009]
Comment
Acts on N-glycoloyl and N-acetyl-derivatives.
Pathway
Amino sugar and nucleotide sugar metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K05304  
sialic acid synthase
Genes
HSA: 
54187(NANS)
PTR: 
743934(NANS)
PPS: 
100982112(NANS)
GGO: 
101124502(NANS)
PON: 
100446862(NANS)
MCC: 
MMU: 
94181(Nans)
RNO: 
298071(Nans)
CFA: 
481624(NANS)
AML: 
100471912(NANS)
FCA: 
101092303(NANS)
BTA: 
540602(NANS)
SSC: 
100155883(NANS)
ECB: 
100064126(NANS)
MDO: 
100014569(NANS)
SHR: 
100915225(NANS)
OAA: 
100074951(NANS)
GGA: 
427283(NANS)
MGP: 
100540972
TGU: 
100227675(NANS)
ACS: 
100558551(nans)
XLA: 
432051 447417(nans)
XTR: 
100492893
DRE: 
322780(nans)
TRU: 
778024(nans)
OLA: 
101166198
BFO: 
BRAFLDRAFT_115797
SPU: 
577884(nans)
DME: 
Dmel_CG5232(Sas)
DPO: 
Dpse_GA18754
DAN: 
Dana_GF17956
DER: 
Dere_GG18905
DPE: 
Dper_GL27311
DSE: 
Dsec_GM24031
DSI: 
Dsim_GD18832
DWI: 
Dwil_GK14403
DYA: 
Dyak_GE26192
DGR: 
Dgri_GH13892
DMO: 
Dmoj_GI24828
DVI: 
Dvir_GJ24471
AGA: 
AgaP_AGAP004460
AAG: 
AaeL_AAEL000097
CQU: 
CpipJ_CPIJ013964
API: 
100166349
PHU: 
Phum_PHUM018360
RLG: 
Rleg_0440
RCE: 
RC1_3771(nans)
 » show all
Taxonomy
Reference
1  [PMID:13743311]
  Authors
ROSEMAN S, JOURDIAN GW, WATSON D, ROOD R.
  Title
Enzymatic synthesis of sialic acid 9-phosphates.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 47 (1961) 958-61.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:5928202]
  Authors
Watson DR, Jourdian GW, Roseman S.
  Title
The sialic acids. 8. Sialic acid 9-phosphate synthetase.
  Journal
J. Biol. Chem. 241 (1966) 5627-36.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:10873658]
  Authors
Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K.
  Title
Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity.
  Journal
Biochem. Biophys. Res. Commun. 273 (2000) 642-8.
  Organism
Mus musculus [GN:mmu]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9031-58-7
DBGET integrated database retrieval system