KEGG   ENZYME: 2.5.1.57Help
Entry
EC 2.5.1.57                 Enzyme                                 

Name
N-acylneuraminate-9-phosphate synthase;
N-acetylneuraminate 9-phosphate lyase;
N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase;
N-acetylneuraminate 9-phosphate synthetase;
N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating);
sialic acid 9-phosphate synthetase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate [RN:R02769]
Reaction(KEGG)
Substrate
phosphoenolpyruvate [CPD:C00074];
N-acyl-D-mannosamine 6-phosphate [CPD:C00686];
H2O [CPD:C00001]
Product
N-acylneuraminate 9-phosphate [CPD:C01200];
phosphate [CPD:C00009]
Comment
Acts on N-glycoloyl and N-acetyl-derivatives.
History
EC 2.5.1.57 created 1972 as EC 4.1.3.20, transferred 2002 to EC 2.5.1.57
Pathway
Amino sugar and nucleotide sugar metabolism
Metabolic pathways
Orthology
K05304  
sialic acid synthase
Genes
HSA: 
54187(NANS)
PTR: 
743934(NANS)
PPS: 
100982112(NANS)
GGO: 
101124502(NANS)
PON: 
100446862(NANS)
NLE: 
MCC: 
715459(NANS)
MCF: 
102120030(NANS)
RRO: 
104657773(NANS)
CJC: 
100411585(NANS)
MMU: 
94181(Nans)
RNO: 
298071(Nans)
CGE: 
100767837(Nans)
NGI: 
103749137(Nans)
HGL: 
101721582(Nans)
OCU: 
100356934(NANS)
TUP: 
102496776(NANS)
CFA: 
481624(NANS)
AML: 
100471912(NANS)
UMR: 
103678504(NANS)
FCA: 
101092303(NANS)
PTG: 
102952743(NANS)
BTA: 
540602(NANS)
BOM: 
102266035(NANS)
PHD: 
102326794(NANS)
CHX: 
102171423(NANS)
OAS: 
101104048(NANS)
SSC: 
100155883(NANS)
CFR: 
102511644(NANS)
BACU: 
103016138(NANS)
LVE: 
103074242(NANS)
ECB: 
100064126(NANS)
MYB: 
102254698(NANS)
MYD: 
102770256(NANS)
PALE: 
102882391(NANS)
MDO: 
100014569(NANS)
SHR: 
100915225(NANS)
OAA: 
100074951(NANS)
GGA: 
427283(NANS)
MGP: 
100540972(NANS)
CJO: 
107306381(NANS)
APLA: 
101793548(NANS)
TGU: 
100227675(NANS)
GFR: 
102036907(NANS)
FAB: 
101817049(NANS)
PHI: 
102108606(NANS)
CCW: 
104689769(NANS)
FPG: 
101910977(NANS)
FCH: 
102058691(NANS)
CLV: 
102088004(NANS)
AAM: 
106487451(NANS)
ASN: 
102371122(NANS)
AMJ: 
102562418(NANS)
PSS: 
102457496(NANS)
CMY: 
102930222(NANS)
ACS: 
100558551(nans)
PBI: 
103051012(NANS)
GJA: 
107122992(NANS)
XLA: 
XTR: 
100492893(nans)
DRE: 
322780(nansa)
TRU: 
778024(nans)
MZE: 
OLA: 
101166198(nans)
XMA: 
102234709(nans)
CMK: 
BFO: 
SPU: 
577884(nans)
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD18832(Dsim_GD18832)
DWI: 
DYA: 
Dyak_GE26192(dyak_GLEANR_9756)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
CRG: 
DGG: 
RLG: 
BVR: 
RCE: 
RC1_3771(nans)
RTX: 
RTC: 
CAMU: 
BGW: 
 » show all
Taxonomy
Reference
1  [PMID:13743311]
  Authors
ROSEMAN S, JOURDIAN GW, WATSON D, ROOD R.
  Title
Enzymatic synthesis of sialic acid 9-phosphates.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 47 (1961) 958-61.
Reference
2  [PMID:5928202]
  Authors
Watson DR, Jourdian GW, Roseman S.
  Title
The sialic acids. 8. Sialic acid 9-phosphate synthetase.
  Journal
J. Biol. Chem. 241 (1966) 5627-36.
Reference
3  [PMID:10873658]
  Authors
Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K.
  Title
Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity.
  Journal
Biochem. Biophys. Res. Commun. 273 (2000) 642-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9031-58-7

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