KEGG   ENZYME: 2.5.1.69Help
Entry
EC 2.5.1.69                 Enzyme                                 

Name
lavandulyl diphosphate synthase;
FDS-5
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming)
Reaction(IUBMB)
2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate [RN:R08950]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235]
Product
diphosphate [CPD:C00013];
lavandulyl diphosphate [CPD:C18052]
Comment
Lavandulyl diphosphate is a monoterpene with a non-head-to-tail linkage. It is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head-to-tail. When this enzyme is incubated with dimethylallyl diphosphate and isopentenyl diphosphate, it also forms the regular monoterpene geranyl diphosphate [2]. The enzyme from Artemisia tridentata (big sagebrush) forms both lavandulyl diphosphate and chrysanthemyl diphosphate (see EC 2.5.1.67, chrysanthemyl diphosphate synthase) when dimethylally diphosphate is the sole substrate.
History
EC 2.5.1.69 created 2007
Reference
1  [PMID:12783539]
  Authors
Erickson HK, Poulter CD.
  Title
Chrysanthemyl diphosphate synthase. The relationship among chain elongation, branching, and cyclopropanation reactions in the isoprenoid biosynthetic pathway.
  Journal
J. Am. Chem. Soc. 125 (2003) 6886-8.
  Sequence
Reference
2  [PMID:12782626]
  Authors
Hemmerlin A, Rivera SB, Erickson HK, Poulter CD.
  Title
Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformis.
  Journal
J. Biol. Chem. 278 (2003) 32132-40.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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