KEGG   ENZYME: 2.5.1.80Help
Entry
EC 2.5.1.80                 Enzyme                                 

Name
7-dimethylallyltryptophan synthase;
7-DMATS
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:L-tryptophan 7-dimethylallyltransferase
Reaction(IUBMB)
dimethylallyl diphosphate + L-tryptophan = diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan [RN:R09638]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
L-tryptophan [CPD:C00078]
Product
diphosphate [CPD:C00013];
7-(3-methylbut-2-enyl)-L-tryptophan [CPD:C19767]
Comment
This enzyme is more flexible towards the aromatic substrate than EC 2.5.1.34 (4-dimethylallyltryptophan synthase), but similar to that enzyme, accepts only dimethylallyl diphosphate as the prenyl donor.
History
EC 2.5.1.80 created 2010
Orthology
K14131  
tryptophan 7-dimethylallyltransferase
Genes
NFI: 
AFM: 
TVE: 
Taxonomy
Reference
1  [PMID:18481055]
  Authors
Kremer A, Li SM
  Title
Potential of a 7-dimethylallyltryptophan synthase as a tool for production of prenylated indole derivatives.
  Journal
Appl. Microbiol. Biotechnol. 79 (2008) 951-61.
  Organism
Aspergillus fumigatus [GN:afm]
  Sequence
Reference
2  [PMID:17906140]
  Authors
Kremer A, Westrich L, Li SM
  Title
A 7-dimethylallyltryptophan synthase from Aspergillus fumigatus: overproduction,  purification and biochemical characterization.
  Journal
Microbiology. 153 (2007) 3409-16.
  Organism
Aspergillus fumigatus [GN:afm]
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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