KEGG   ENZYME: 2.5.1.82Help
Entry
EC 2.5.1.82                 Enzyme                                 

Name
hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific];
HexPS(ambiguous);
(all-E) hexaprenyl diphosphate synthase;
(all-trans) hexaprenyl diphosphate synthase;
hexaprenyl pyrophosphate synthase (ambiguous);
HexPPs (ambiguous);
hexaprenyl diphosphate synthase (ambiguous)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units)
Reaction(IUBMB)
geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate [RN:R09246]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-hexaprenyl diphosphate [CPD:C01230]
Comment
The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. Requires Mg2+ [1].
History
EC 2.5.1.82 created 1984 as EC 2.5.1.33, part transferred 2010 to EC 2.5.1.82
Pathway
Terpenoid backbone biosynthesis
Biosynthesis of secondary metabolites
Orthology
K05355  
hexaprenyl-diphosphate synthase
Genes
CME: 
SCE: 
YBR003W(COQ1)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0I01970(NCAS0I01970)
NDI: 
NDAI_0A06570(NDAI0A06570)
TPF: 
TPHA_0A04460(TPHA0A04460)
TBL: 
TBLA_0F00560(TBLA0F00560)
TDL: 
TDEL_0D04200(TDEL0D04200)
KAF: 
KAFR_0F02550(KAFR0F02550)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT124027(NEUTE1DRAFT_124027)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
AFM: 
AOR: 
AOR_1_148084(AO090020000085)
ANG: 
ANI_1_1348094(An11g10370)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT117445(AGABI1DRAFT_117445) AGABI1DRAFT121951(AGABI1DRAFT_121951)
ABV: 
AGABI2DRAFT123328(AGABI2DRAFT_123328) AGABI2DRAFT214023(AGABI2DRAFT_214023)
CPUT: 
SLA: 
WSE: 
WIC: 
PFP: 
MGL: 
PGR: 
MLR: 
DFA: 
DFA_03641(coq1)
PSOJ: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:11790729]
  Authors
Hemmi H, Ikejiri S, Yamashita S, Nishino T
  Title
Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus.
  Journal
J. Bacteriol. 184 (2002) 615-20.
  Sequence
[sso:SSO2345]
Reference
2  [PMID:12372398]
  Authors
Hemmi H, Noike M, Nakayama T, Nishino T
  Title
Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus  solfataricus by introducing mimetic mutations.
  Journal
Biochem. Biophys. Res. Commun. 297 (2002) 1096-101.
Reference
3  [PMID:16291686]
  Authors
Sun HY, Ko TP, Kuo CJ, Guo RT, Chou CC, Liang PH, Wang AH
  Title
Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures.
  Journal
J. Bacteriol. 187 (2005) 8137-48.
  Sequence
[sso:SSO2345]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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