KEGG   ENZYME: 2.5.1.86Help
Entry
EC 2.5.1.86                 Enzyme                                 

Name
trans,polycis-decaprenyl diphosphate synthase;
Rv2361c;
(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesylcistransferase (adding 7 isopentenyl units)
Reaction(IUBMB)
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + trans,octacis-decaprenyl diphosphate [RN:R09244]
Reaction(KEGG)
Substrate
(2Z,6E)-farnesyl diphosphate [CPD:C16826];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
trans,octacis-decaprenyl diphosphate
Comment
The enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan [2].
History
EC 2.5.1.86 created 2010
Pathway
Terpenoid backbone biosynthesis
Orthology
K14215  
trans,polycis-decaprenyl diphosphate synthase
Genes
MTU: 
Rv2361c(uppS)
MTV: 
MTC: 
MT2430(uppS-2)
MRA: 
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTI: 
MTE: 
MTUR: 
MTL: 
MTO: 
MTD: 
MTN: 
MTJ: 
MTUB: 
MTUC: 
MTUE: 
MTX: 
MTUH: 
MTUL: 
MTUT: 
MTUU: 
MTQ: 
MBO: 
MBB: 
MBT: 
MBM: 
MBK: 
MBX: 
MBZ: 
MAF: 
MCE: 
MCQ: 
MCV: 
MCX: 
MCZ: 
MMIC: 
MLE: 
MLB: 
MPA: 
MAO: 
MAVI: 
MAVU: 
MAV: 
MAV_2034(uppS)
MAVD: 
MAVR: 
MAVA: 
MIT: 
MIR: 
MIA: 
MIE: 
MID: 
MYO: 
MSM: 
MSG: 
MSB: 
MSN: 
MSH: 
MSA: 
MUL: 
MVA: 
MGI: 
MSP: 
MAB: 
MABB: 
MMV: 
MAY: 
MABO: 
MABL: 
MAZ: 
MAK: 
MYS: 
MYC: 
MMC: 
MKM: 
MJL: 
MJD: 
MMI: 
MRH: 
MMM: 
MCB: 
MLI: 
MKN: 
MKS: 
MKI: 
MNE: 
MYV: 
MYE: 
MGO: 
MFT: 
MHAD: 
MPHL: 
SVL: 
 » show all
Taxonomy
Reference
1  [PMID:15516568]
  Authors
Kaur D, Brennan PJ, Crick DC
  Title
Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis.
  Journal
J. Bacteriol. 186 (2004) 7564-70.
  Sequence
[mtu:Rv2361c]
Reference
2  [PMID:18597781]
  Authors
Wang W, Dong C, McNeil M, Kaur D, Mahapatra S, Crick DC, Naismith JH
  Title
The structural basis of chain length control in Rv1086.
  Journal
J. Mol. Biol. 381 (2008) 129-40.
  Sequence
[mtu:Rv2361c]
Reference
3  [PMID:11004176]
  Authors
Crick DC, Schulbach MC, Zink EE, Macchia M, Barontini S, Besra GS, Brennan PJ
  Title
Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.
  Journal
J. Bacteriol. 182 (2000) 5771-8.
  Sequence
[mtu:Rv2361c] [msm:MSMEG_4490]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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