KEGG   ENZYME: 2.5.1.93Help
Entry
EC 2.5.1.93                 Enzyme                                 

Name
4-hydroxybenzoate geranyltransferase;
PGT1;
PGT2;
4HB geranyltransferase;
4HB:geranyltransferase;
p-hydroxybenzoate geranyltransferase;
PHB geranyltransferase;
geranyl diphosphate:4-hydroxybenzoate geranyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranyl-diphosphate:4-hydroxybenzoate 3-geranyltransferase
Reaction(IUBMB)
geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate [RN:R09040]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
4-hydroxybenzoate [CPD:C00156]
Product
3-geranyl-4-hydroxybenzoate;
diphosphate [CPD:C00013]
Comment
The enzyme is involved in shikonin biosynthesis. It has a strict substrate specificity for geranyl diphosphate and an absolute requirement for Mg2+ [2].
History
EC 2.5.1.93 created 2010
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Biosynthesis of secondary metabolites
Orthology
K13565  
4-hydroxybenzoate geranyltransferase
Reference
1  [PMID:19392660]
  Authors
Ohara K, Muroya A, Fukushima N, Yazaki K
  Title
Functional characterization of LePGT1, a membrane-bound prenyltransferase involved in the geranylation of p-hydroxybenzoic acid.
  Journal
Biochem. J. 421 (2009) 231-41.
  Sequence
Reference
2  [PMID:9640665]
  Authors
Muhlenweg A, Melzer M, Li SM, Heide L
  Title
4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon: purification of a plant membrane-bound prenyltransferase.
  Journal
Planta. 205 (1998) 407-13.
  Sequence
Reference
3  [PMID:11744717]
  Authors
Yazaki K, Kunihisa M, Fujisaki T, Sato F.
  Title
Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis.
  Journal
J. Biol. Chem. 277 (2002) 6240-6.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system