KEGG   ENZYME: 2.5.1.94Help
Entry
EC 2.5.1.94                 Enzyme                                 

Name
adenosyl-chloride synthase;
chlorinase;
5'-chloro-5'-deoxyadenosine synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:chloride adenosyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + chloride = 5-deoxy-5-chloroadenosine + L-methionine [RN:R09639]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
chloride [CPD:C00698]
Product
5-deoxy-5-chloroadenosine [CPD:C19768];
L-methionine [CPD:C00073]
Comment
This enzyme, isolated from the marine bacterium Salinispora tropica, catalyses an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. The enzyme is very similar to EC 2.5.1.63, adenosyl-fluoride synthase, but does not accept fluoride.
History
EC 2.5.1.94 created 2011
Reference
1  [PMID:18059261]
  Authors
Eustaquio AS, Pojer F, Noel JP, Moore BS
  Title
Discovery and characterization of a marine bacterial SAM-dependent chlorinase.
  Journal
Nat. Chem. Biol. 4 (2008) 69-74.
  Organism
Salinispora tropica
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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