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Entry
EC 2.6.1.102                Enzyme                                 

Name
GDP-perosamine synthase;
RfbE;
GDP-4-keto-6-deoxy-D-mannose-4-aminotransferase;
GDP-perosamine synthetase;
PerA;
GDP-4-amino-4,6-dideoxy-alpha-D-mannose:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
GDP-alpha-D-perosamine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
GDP-alpha-D-perosamine + 2-oxoglutarate = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate [RN:R10460]
Reaction(KEGG)
Substrate
GDP-alpha-D-perosamine [CPD:C20638];
2-oxoglutarate [CPD:C00026]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:C01222];
L-glutamate [CPD:C00025]
Comment
A pyridoxal 5'-phosphate enzyme. D-Perosamine is one of several dideoxy sugars found in the O-specific polysaccharide of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. The enzyme catalyses the final step in GDP-alpha-D-perosamine synthesis.
History
EC 2.6.1.102 created 2013
Pathway
Amino sugar and nucleotide sugar metabolism
Orthology
K13010  
perosamine synthetase
Genes
ECE: 
Z3200(per)
ECS: 
ECF: 
ETW: 
ELX: 
YEP: 
YET: 
XAX: 
VCH: 
VCE: 
VCJ: 
VCO: 
VCR: 
VCM: 
VCI: 
VCL: 
LAG: 
PFO: 
PPUU: 
PAT: 
MMT: 
MAH: 
FPH: 
AHA: 
RPI: 
RPF: 
BPS: 
BPM: 
BPL: 
BPD: 
BPSE: 
BPZ: 
BPQ: 
BPK: 
BTE: 
PNU: 
VEI: 
CBX: 
MPT: 
RGE: 
AZA: 
SDR: 
SLT: 
HCP: 
HCB: 
GSK: 
GUR: 
GLO: 
GBM: 
Gbem_2577(rfbE)
GEM: 
DHY: 
DAK: 
DTO: 
ADE: 
ANK: 
SAT: 
DAO: 
DTI: 
RLE: 
RLT: 
RLG: 
BME: 
BMEL: 
BMI: 
BMZ: 
BMG: 
BMW: 
BMEE: 
BMF: 
BMB: 
BMC: 
BAA: 
BABO: 
BABR: 
BABT: 
BABB: 
BABU: 
BABS: 
BABC: 
BMS: 
BSI: 
BSF: 
BSUI: 
BSUP: 
BSUV: 
BSUC: 
BMT: 
BSZ: 
BSV: 
BSW: 
BSG: 
BOV: 
BCS: 
BSK: 
BOL: 
BCAR: 
BCAS: 
BMR: 
BPP: 
BPV: 
BCET: 
BCEE: 
BRS: 
NWI: 
AZC: 
SNO: 
MET: 
MNO: 
HNI: 
CCR: 
CCS: 
CSE: 
RLI: 
SJP: 
ACR: 
MAG: 
MGY: 
APM: 
BCG: 
BTI: 
BTN: 
BWE: 
GKA: 
GTH: 
LSP: 
BBE: 
PJD: 
GYM: 
PMS: 
PMQ: 
PMW: 
BTS: 
CNO: 
CBL: 
CBB: 
CBN: 
CBT: 
CBF: 
CBM: 
CLE: 
DRM: 
PTH: 
PTH_1115(WecE)
DOR: 
DMI: 
TIT: 
MTA: 
TXY: 
TSH: 
MAS: 
AAR: 
MIT: 
MIR: 
MIA: 
MKN: 
KSK: 
PDX: 
VMA: 
SYN: 
slr1615(rfbE) slr2114(spsC)
SYZ: 
MYO_114890(spsC) MYO_13370(rfbE)
SYY: 
SYT: 
SYS: 
SYQ: 
SYC: 
syc1444_d(rfbE)
SYF: 
MAR: 
CYT: 
CYP: 
CYH: 
CGC: 
CMP: 
ANB: 
CALO: 
CTHE: 
PLP: 
CAP: 
ABA: 
PHM: 
SRU: 
PSN: 
GFO: 
FBC: 
PMX: 
TNP: 
MPZ: 
DIN: 
CNI: 
DTU: 
MMP: 
MMP0351(aspB-like1)
MAE: 
MVO: 
MBU: 
MTP: 
MCJ: 
MHU: 
MEM: 
MBG: 
MBN: 
MFO: 
MTH: 
AST: 
FPL: 
FAC: 
PAB: 
PAB0774(aspB-like1)
PFU: 
PFI: 
TGA: 
TGAM_2150(degT)
TSI: 
TBA: 
TLT: 
ACF: 
IAG: 
SIS: 
FFO: 
KCR: 
 » show all
Taxonomy
Reference
1  [PMID:11479276]
  Authors
Albermann C, Piepersberg W
  Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
  Journal
Glycobiology. 11 (2001) 655-61.
Reference
2  [PMID:17888872]
  Authors
Zhao G, Liu J, Liu X, Chen M, Zhang H, Wang PG
  Title
Cloning and characterization of GDP-perosamine synthetase (Per) from Escherichia  coli O157:H7 and synthesis of GDP-perosamine in vitro.
  Journal
Biochem. Biophys. Res. Commun. 363 (2007) 525-30.
Reference
3  [PMID:18201574]
  Authors
Albermann C, Beuttler H
  Title
Identification of the GDP-N-acetyl-d-perosamine producing enzymes from Escherichia coli O157:H7.
  Journal
FEBS. Lett. 582 (2008) 479-84.
Reference
4  [PMID:18795799]
  Authors
Cook PD, Carney AE, Holden HM
  Title
Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase.
  Journal
Biochemistry. 47 (2008) 10685-93.
  Sequence
[ccr:CC_1012]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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