KEGG   ENZYME: 2.6.1.103Help
Entry
EC 2.6.1.103                Enzyme                                 

Name
(S)-3,5-dihydroxyphenylglycine transaminase;
HpgT
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
(S)-3,5-dihydroxyphenylglycine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate [RN:R06634]
Reaction(KEGG)
R06634;
(other) R06626
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Substrate
(S)-3,5-dihydroxyphenylglycine [CPD:C12026];
2-oxoglutarate [CPD:C00026]
Product
2-(3,5-dihydroxyphenyl)-2-oxoacetate [CPD:C12325];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-5'-phosphate protein. The enzyme from the bacterium Amycolatopsis orientalis catalyses the reaction in the reverse direction as part of the biosynthesis of the (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin.
History
EC 2.6.1.103 created 2013
Pathway
Monobactam biosynthesis
Biosynthesis of vancomycin group antibiotics
Biosynthesis of antibiotics
Orthology
K16423  
(S)-3,5-dihydroxyphenylglycine transaminase
Genes
SMAF: 
DDA: 
PLU: 
XAL: 
XTN: 
PFE: 
PBA: 
PBC: 
HCH: 
BGL: 
BGP: 
BGU: 
BGD: 
BGO: 
BPLA: 
AGE: 
SCO: 
SCO3227(SCE63.06)
SVL: 
SBH: 
SHY: 
SHO: 
SALS: 
SRC: 
SALU: 
SALL: 
SLV: 
SVT: 
STRE: 
SXI: 
STRC: 
SAMB: 
SPRI: 
KSK: 
KFL: 
NDA: 
NAL: 
FRA: 
AOI: 
AJA: 
ALU: 
AMI: 
KAL: 
STP: 
SAQ: 
MAU: 
MIL: 
VMA: 
CAI: 
 » show all
Taxonomy
Reference
1
  Authors
Sandercock, A.M., Charles, E.H., Scaife, W., Kirkpatrick, P.N., O'Brien, S.W., Papageorgiou, E.A., Spencer, J.B. and Williams, D.H.
  Title
Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin.
  Journal
Chem. Comm. (2001) 1252-1253.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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