KEGG   ENZYME: 2.6.1.105Help
Entry
EC 2.6.1.105                Enzyme                                 

Name
lysine---8-amino-7-oxononanoate transaminase;
DAPA aminotransferase (ambiguous);
bioA (gene name) (ambiguous);
bioK (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-lysine:8-amino-7-oxononanoate aminotransferase
Reaction(IUBMB)
L-lysine + 8-amino-7-oxononanoate = (S)-2-amino-6-oxohexanoate + 7,8-diaminononanoate [RN:R10699]
Reaction(KEGG)
Substrate
L-lysine [CPD:C00047];
8-amino-7-oxononanoate [CPD:C01092]
Product
(S)-2-amino-6-oxohexanoate [CPD:C04076];
7,8-diaminononanoate [CPD:C01037]
Comment
A pyridoxal 5'-phosphate enzyme [2]. Participates in the pathway for biotin biosynthesis. The enzyme from the bacterium Bacillus subtilis cannot use S-adenosyl-L-methionine as amino donor and catalyses an alternative reaction for the conversion of 8-amino-7-oxononanoate to 7,8-diaminononanoate (cf. EC 2.6.1.62, adenosylmethionine---8-amino-7-oxononanoate transaminase).
History
EC 2.6.1.105 created 2014
Pathway
Biotin metabolism
Metabolic pathways
Orthology
K19563  
lysine---8-amino-7-oxononanoate aminotransferase
Genes
BSU: 
BSU30230(bioA)
BSR: 
I33_3077(bioA)
BSL: 
BSH: 
BSY: 
BSUT: 
BSUL: 
BSUS: 
BSS: 
BST: 
GYO_3271(bioA)
BSO: 
BSN: 
BSQ: 
BSX: 
C663_2868(bioK)
BSP: 
BLI: 
BL00953(bioA)
BLD: 
BLi00767(bioA)
BLH: 
BAY: 
BAQ: 
BYA: 
BAMP: 
BAML: 
BAMA: 
RBAU_1803(bioK)
BAMN: 
BASU_1783(bioK)
BAMB: 
BAMT: 
BAMY: 
BMP: 
BAO: 
BAMF_1923(bioK)
BAZ: 
BQL: 
LL3_02013(bioK)
BXH: 
BQY: 
MUS_2182(bioA)
BAMI: 
BAMC: 
BAMF: 
BAE: 
BATR: 
BJS: 
BACI: 
BACP: 
BACB: 
BACO: 
BACY: 
BACL: 
BALM: 
BEO: 
AGN: 
VIR: 
LKI: 
LEC: 
 » show all
Taxonomy
Reference
1  [PMID:15880481]
  Authors
Van Arsdell SW, Perkins JB, Yocum RR, Luan L, Howitt CL, Chatterjee NP, Pero JG
  Title
Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction.
  Journal
Biotechnol. Bioeng. 91 (2005) 75-83.
  Sequence
[bsu:BSU30230]
Reference
2  [PMID:20565114]
  Authors
Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC
  Title
Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
  Journal
Biochemistry. 49 (2010) 6746-60.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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