KEGG   ENZYME: 2.6.1.106Help
Entry
EC 2.6.1.106                Enzyme                                 

Name
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase;
desV (gene name);
megDII (gene name);
eryCI (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose + L-glutamate [RN:R06426]
Reaction(KEGG)
Substrate
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose [CPD:C11910];
2-oxoglutarate [CPD:C00026]
Product
dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose [CPD:C11909];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin. The reaction occurs in the reverse direction.
History
EC 2.6.1.106 created 2014
Pathway
Polyketide sugar unit biosynthesis
Biosynthesis of antibiotics
Orthology
K13310  
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
K16436  
dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase
Genes
NBR: 
SGR: 
SXI: 
SAMB: 
NDA: 
NAL: 
TCU: 
SEN: 
SACE_0734(eryCI)
SVI: 
AOI: 
AJA: 
ALU: 
SESP: 
BN6_58910(sam30)
KAL: 
KALB_6580(acuN1)
KPHY: 
SAQ: 
MAU: 
MIL: 
AMS: 
 » show all
Taxonomy
Reference
1  [PMID:17456741]
  Authors
Burgie ES, Thoden JB, Holden HM
  Title
Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine.
  Journal
Protein. Sci. 16 (2007) 887-96.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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