KEGG   ENZYME: 2.6.1.23Help
Entry
EC 2.6.1.23                 Enzyme                                 

Name
4-hydroxyglutamate transaminase;
4-hydroxyglutamate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase
Reaction(IUBMB)
4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate [RN:R03266]
Reaction(KEGG)
Substrate
4-hydroxy-L-glutamate [CPD:C03079];
2-oxoglutarate [CPD:C00026]
Product
4-hydroxy-2-oxoglutarate [CPD:C01127];
L-glutamate [CPD:C00025]
Comment
Oxaloacetate can replace 2-oxoglutarate. This enzyme may be identical with EC 2.6.1.1 aspartate transaminase.
History
EC 2.6.1.23 created 1972, modified 1982
Pathway
Arginine and proline metabolism
Reference
1  [PMID:13948827]
  Authors
GOLDSTONE A, ADAMS E.
  Title
Metabolism of gamma-hydroxyglutamic acid. I. Conversion to alpha-hydroxy-gamma-ketoglutarate by purified glutamic-aspartic transaminase to rat liver.
  Journal
J. Biol. Chem. 237 (1962) 3476-85.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:14089443]
  Authors
KURATOMI K, FUKUNAGA K, KOBAYASHI Y.
  Title
THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT  LIVER. II. A TRANSAMINASE CONCERNED IN GAMMA-HYDROXYGLUTAMATE METABOLISM.
  Journal
Biochim. Biophys. Acta. 78 (1963) 629-36.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37277-86-4

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