| Entry |
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| Name |
thyroid-hormone transaminase;
3,5-dinitrotyrosine transaminase;
thyroid hormone aminotransferase
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
 |
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| Sysname |
L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase
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| Reaction(IUBMB) |
L-3,5,3'-triiodothyronine + 2-oxoglutarate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate [RN: R03952]
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| Reaction(KEGG) |
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| Substrate |
L-3,5,3'-triiodothyronine [CPD: C02465];
2-oxoglutarate [CPD: C00026]
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| Product |
3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate [CPD: C03832];
L-glutamate [CPD: C00025]
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| Comment |
A pyridoxal-phosphate protein. Acts on monoiodotyrosine, diiodotyrosine, triiodothyronine, thyroxine and dinitrotyrosine (unlike EC 2.6.1.24 diiodotyrosine transaminase, which does not act on dinitrotyrosine). Pyruvate or oxaloacetate can act as acceptors.
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| Reference |
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| Authors |
Soffer RL, Hechtman P, Savage M. |
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| Title |
L-Triiodothyronine aminotransferase. |
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| Journal |
J. Biol. Chem. 248 (1973) 1224-30. |
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| Organism |
Oryctolagus cuniculus |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 51004-29-6 |
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