KEGG   ENZYME: 2.6.1.27Help
Entry
EC 2.6.1.27                 Enzyme                                 

Name
tryptophan transaminase;
L-phenylalanine-2-oxoglutarate aminotransferase;
tryptophan aminotransferase;
5-hydroxytryptophan-ketoglutaric transaminase;
hydroxytryptophan aminotransferase;
L-tryptophan aminotransferase;
L-tryptophan transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-tryptophan:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate [RN:R00684]
Reaction(KEGG)
R00684;
(other) R02700
Show
Substrate
L-tryptophan [CPD:C00078];
2-oxoglutarate [CPD:C00026]
Product
(indol-3-yl)pyruvate [CPD:C00331];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. Also acts on 5-hydroxytryptophan and, to a lesser extent, on the phenyl amino acids.
History
EC 2.6.1.27 created 1972
Pathway
Tryptophan metabolism
Metabolic pathways
Orthology
K00838  
aromatic amino acid aminotransferase I
K14265  
tryptophan aminotransferase
Genes
SCE: 
YGL202W(ARO8)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0E00670(NCAS0E00670)
NDI: 
NDAI_0I02830(NDAI0I02830)
TPF: 
TPHA_0D03370(TPHA0D03370)
TDL: 
TDEL_0D05790(TDEL0D05790)
KAF: 
KAFR_0D01420(KAFR0D01420)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
TRE: 
VAL: 
SSL: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_454014(AO090026000245) AOR_1_786084(AO090020000444)
ANG: 
ANI_1_1292134(An15g02460) ANI_1_766024(An02g05540)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
NGD: 
 » show all
Taxonomy
Reference
1  [PMID:5722279]
  Authors
George H, Gabay S.
  Title
Brain aromatic aminotransferase. I. Purification and some properties of pig brain L-phenylalanine-2-oxoglutarate aminotransferase.
  Journal
Biochim. Biophys. Acta. 167 (1968) 555-66.
  Organism
Sus scofa
Reference
2  [PMID:5697992]
  Authors
O'Neil SR, DeMoss RD.
  Title
Tryptophan transaminase from Clostridium sporogenes.
  Journal
Arch. Biochem. Biophys. 127 (1968) 361-9.
  Organism
Clostridium sporogenes
Reference
3  [PMID:14285270]
  Authors
TANGEN O, FONNUM F, HAAVALDSEN R.
  Title
SEPARATION AND PURIFICATION OF AROMATIC AMINO ACID TRANSAMINASES FROM RAT BRAIN.
  Journal
Biochim. Biophys. Acta. 96 (1965) 82-90.
  Organism
Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9022-98-4

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