KEGG   ENZYME: 2.6.1.27Help
Entry
EC 2.6.1.27                 Enzyme                                 
Name
tryptophan transaminase;
L-phenylalanine-2-oxoglutarate aminotransferase;
tryptophan aminotransferase;
5-hydroxytryptophan-ketoglutaric transaminase;
hydroxytryptophan aminotransferase;
L-tryptophan aminotransferase;
L-tryptophan transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-tryptophan:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate [RN:R00684]
Reaction(KEGG)
R00684;
(other) R02700
Show
Substrate
L-tryptophan [CPD:C00078];
2-oxoglutarate [CPD:C00026]
Product
(indol-3-yl)pyruvate [CPD:C00331];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. Also acts on 5-hydroxytryptophan and, to a lesser extent, on the phenyl amino acids.
Pathway
Tryptophan metabolism
Metabolic pathways
Orthology
K00838  
aromatic amino acid aminotransferase I
K14265  
tryptophan aminotransferase
Genes
SCE: 
YGL202W(ARO8)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0E00670(NCAS0E00670)
NDI: 
NDAI_0I02830(NDAI0I02830)
TPF: 
TPHA_0D03370(TPHA0D03370)
TDL: 
TDEL_0D05790(TDEL0D05790)
KAF: 
KAFR_0D01420(KAFR0D01420)
DHA: 
DEHA2A06886g
PIC: 
PICST_66767(ARO8)
PGU: 
PGUG_02078 PGUG_04621
LEL: 
LELG_01198
CAL: 
CaO19.2098(ARO8) CaO19.9645(ARO8)
CTP: 
CTRG_01079
CDU: 
CD36_15310
COT: 
CORT_0A12760
YLI: 
YALI0E20977g
CLU: 
CLUG_00783
NCR: 
NCU09116
SMP: 
SMAC_04612
PAN: 
PODANSg5646
TTT: 
THITE_2121569
MTM: 
MYCTH_2294749
MGR: 
MGG_09919
FGR: 
FG01285.1
NHE: 
NECHADRAFT_51829 NECHADRAFT_74483
VAL: 
VDBG_04940
SSL: 
SS1G_10035
BFU: 
BC1G_07219
ANI: 
AN6338.2 AN8519.2
NFI: 
NFIA_088830
AFM: 
AFUA_2G13630
AOR: 
AOR_1_454014(AO090026000245)
ANG: 
ANI_1_766024(An02g05540)
AFV: 
AFLA_099700 AFLA_136830
ACT: 
ACLA_073980
PCS: 
Pc12g11860
CIM: 
CIMG_04628
CPW: 
CPC735_071790
PBL: 
PAAG_05743
URE: 
UREG_01826
ABE: 
ARB_01306
TVE: 
TRV_00012
AJE: 
HCAG_04617
PNO: 
SNOG_04259
PTE: 
PTT_08476
ZTR: 
MYCGRDRAFT_100367
TML: 
GSTUM_00008805001
SPO: 
SPAC56E4.03 SPBC1773.13 SPCC569.07
CNE: 
CNF01590 CNF04620
CNB: 
CNBB2510 CNBF0280 CNBF3120
CGI: 
CGB_A3370W
PPL: 
POSPLDRAFT_89909
LBC: 
LACBIDRAFT_191053 LACBIDRAFT_311755
MPR: 
MPER_11136
CCI: 
CC1G_07874 CC1G_14996
SCM: 
SCHCODRAFT_105805 SCHCODRAFT_15733 SCHCODRAFT_62391 SCHCODRAFT_66984 SCHCODRAFT_80399
UMA: 
UM01804.1
MGL: 
MGL_2601
 » show all
Taxonomy
Reference
1  [PMID:5722279]
  Authors
George H, Gabay S.
  Title
Brain aromatic aminotransferase. I. Purification and some properties of pig brain L-phenylalanine-2-oxoglutarate aminotransferase.
  Journal
Biochim. Biophys. Acta. 167 (1968) 555-66.
  Organism
Sus scofa [GN:ssc]
Reference
2  [PMID:5697992]
  Authors
O'Neil SR, DeMoss RD.
  Title
Tryptophan transaminase from Clostridium sporogenes.
  Journal
Arch. Biochem. Biophys. 127 (1968) 361-9.
  Organism
Clostridium sporogenes
Reference
3  [PMID:14285270]
  Authors
TANGEN O, FONNUM F, HAAVALDSEN R.
  Title
SEPARATION AND PURIFICATION OF AROMATIC AMINO ACID TRANSAMINASES FROM RAT BRAIN.
  Journal
Biochim. Biophys. Acta. 96 (1965) 82-90.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9022-98-4
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