| Entry |
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| Name |
UDP-N-acetylbacillosamine transaminase;
uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase;
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase;
UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase;
pglE (gene name);
UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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| Sysname |
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine:2-oxoglutarate aminotransferase
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| Reaction(IUBMB) |
UDP-N-acetylbacillosamine + 2-oxoglutarate = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + L-glutamate [RN: R04529]
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| Reaction(KEGG) |
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| Substrate |
UDP-N-acetylbacillosamine [CPD: C04630];
2-oxoglutarate [CPD: C00026]
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| Product |
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose [CPD: C04613];
L-glutamate [CPD: C00025]
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| Comment |
A pyridoxal-phosphate protein. The enzyme is involved in biosynthesis of UDP-N,N'-diacetylbacillosamine, an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [2-4] and O-linked glycosylation of certain L-serine residues in Neisseria species [5].
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| History |
EC 2.6.1.34 created 1972, modified 2013
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| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
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| Orthology |
| K15910 | UDP-N-acetylbacillosamine transaminase |
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| Genes |
» show all
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| Reference |
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| Authors |
Distler J, Kaufman B, Roseman S. |
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| Title |
Enzymic synthesis of a diamino sugar nucleotide by extracts of type XIV Diplococcus pneumoniae. |
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| Journal |
Arch. Biochem. Biophys. 116 (1966) 466-78. |
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| Reference |
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| Authors |
Olivier NB, Chen MM, Behr JR, Imperiali B |
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| Title |
In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system. |
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| Journal |
Biochemistry. 45 (2006) 13659-69. |
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| Reference |
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| Authors |
Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM |
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| Title |
Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways. |
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| Journal |
J. Biol. Chem. 281 (2006) 723-32. |
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| Sequence |
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| Reference |
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| Authors |
Rangarajan ES, Ruane KM, Sulea T, Watson DC, Proteau A, Leclerc S, Cygler M, Matte A, Young NM |
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| Title |
Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter jejuni. |
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| Journal |
Biochemistry. 47 (2008) 1827-36. |
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| Reference |
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| Authors |
Hartley MD, Morrison MJ, Aas FE, Borud B, Koomey M, Imperiali B |
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| Title |
Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N'-diacetylbacillosamine. |
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| Journal |
Biochemistry. 50 (2011) 4936-48. |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.6.1.34 |
| ExPASy - ENZYME nomenclature database: | 2.6.1.34 |
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