KEGG   ENZYME: 2.6.1.34Help
Entry
EC 2.6.1.34                 Enzyme                                 

Name
UDP-N-acetylbacillosamine transaminase;
uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase;
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase;
UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase;
pglE (gene name);
UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
UDP-N-acetylbacillosamine + 2-oxoglutarate = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + L-glutamate [RN:R04529]
Reaction(KEGG)
Substrate
UDP-N-acetylbacillosamine [CPD:C04630];
2-oxoglutarate [CPD:C00026]
Product
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose [CPD:C04613];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The enzyme is involved in biosynthesis of UDP-N,N'-diacetylbacillosamine, an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [2-4] and O-linked glycosylation of certain L-serine residues in Neisseria species [5].
History
EC 2.6.1.34 created 1972, modified 2013
Pathway
Amino sugar and nucleotide sugar metabolism
Orthology
K15910  
UDP-N-acetylbacillosamine transaminase
Genes
CJE: 
Cj1121c(pglE)
CJB: 
CJJ: 
CJU: 
C8J_1062(wlaK)
CJN: 
CJI: 
CJSA_1063(pglE)
CJM: 
CJM1_1100(pglE)
CJS: 
CJP: 
CJEJ: 
CJEU: 
N565_01132
CJEN: 
N755_01125
CJEI: 
N135_01158
CJER: 
H730_06580
CJV: 
MTVDSCj20_1125(pglE)
CJY: 
QZ67_01198(pglE)
CJQ: 
UC78_1079(pglE)
CJL: 
PJ17_05750
CJW: 
PJ18_05560
CJR: 
CJE1264(pglE)
CJD: 
JJD26997_0599(pglE)
CJZ: 
M635_01310
CJX: 
BN867_11130
CFF: 
CFF8240_1355
CFT: 
CFF04554_1371(pglE)
CFV: 
CFVI03293_1394(pglE)
CFX: 
CFV97608_1494(pglE)
CFZ: 
CSG_14940
CAMP: 
CFT03427_1319(pglE)
CFP: 
CR44_06675
CCV: 
CCV52592_1203(pglE)
CHA: 
CHAB381_0950
CCO: 
CCC13826_0448(pglE)
CCOC: 
CCON33237_1461(pglE)
CLA: 
Cla_1257(pglE)
CLR: 
UPTC16701_1240(pglE)
CLM: 
UPTC16712_1258(pglE)
CLQ: 
UPTC4110_1242(pglE)
CLN: 
UPTC3659_1477(pglE)
CLL: 
CONCH_1208(pglE)
CCOL: 
BN865_10070
CCC: 
G157_03325
CCQ: 
N149_1063
CCF: 
YSQ_03360
CCY: 
YSS_06075
CCOI: 
YSU_03395
CCOF: 
VC76_05505(pglE)
CCOO: 
ATE51_01360(pglE)
CAJ: 
CIG1485E_1366(pglE)
CIS: 
CINS_1222(pglE)
CVO: 
CVOL_1236(pglE)
CPEL: 
CPEL_1363(pglE)
CAMR: 
CAQ16704_1268(pglE)
CSM: 
CSUB8521_1444(pglE)
CSF: 
CSUB8523_1540(pglE)
CGRA: 
CGRAC_1486(pglE)
CURE: 
CUREO_1369(pglE)
CHYO: 
CHH_1360(pglE)
CHV: 
CHELV3228_0574(pglE)
SLH: 
YH65_07060
 » show all
Taxonomy
Reference
1  [PMID:4381351]
  Authors
Distler J, Kaufman B, Roseman S.
  Title
Enzymic synthesis of a diamino sugar nucleotide by extracts of type XIV Diplococcus pneumoniae.
  Journal
Arch. Biochem. Biophys. 116 (1966) 466-78.
Reference
2  [PMID:17087520]
  Authors
Olivier NB, Chen MM, Behr JR, Imperiali B
  Title
In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system.
  Journal
Biochemistry. 45 (2006) 13659-69.
Reference
3  [PMID:16286454]
  Authors
Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM
  Title
Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways.
  Journal
J. Biol. Chem. 281 (2006) 723-32.
  Sequence
[cje:Cj1121c]
Reference
4  [PMID:18198901]
  Authors
Rangarajan ES, Ruane KM, Sulea T, Watson DC, Proteau A, Leclerc S, Cygler M, Matte A, Young NM
  Title
Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter  jejuni.
  Journal
Biochemistry. 47 (2008) 1827-36.
Reference
5  [PMID:21542610]
  Authors
Hartley MD, Morrison MJ, Aas FE, Borud B, Koomey M, Imperiali B
  Title
Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N'-diacetylbacillosamine.
  Journal
Biochemistry. 50 (2011) 4936-48.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37277-89-7
DBGET integrated database retrieval system