| Entry |
|
| Name |
L-lysine 6-transaminase;
lysine 6-aminotransferase;
lysine epsilon-aminotransferase;
lysine epsilon-transaminase;
lysine:2-ketoglutarate 6-aminotransferase;
L-lysine-alpha-ketoglutarate aminotransferase;
L-lysine-alpha-ketoglutarate 6-aminotransferase |
| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
 |
| Sysname |
L-lysine:2-oxoglutarate 6-aminotransferase |
| Reaction(IUBMB) |
L-lysine + 2-oxoglutarate = 2-aminoadipate 6-semialdehyde +
L-glutamate [RN:R00457] |
| Reaction(KEGG) |
R00457
 |
| Substrate |
L-lysine [CPD:C00047];
2-oxoglutarate [CPD:C00026] |
| Product |
2-aminoadipate 6-semialdehyde [CPD:C04076];
L-glutamate [CPD:C00025] |
| Cofactor |
Pyridoxal phosphate [CPD:C00018] |
| Comment |
A pyridoxal-phosphate protein. The product (allysine) is converted
into the intramolecularly dehydrated form, 1-piperideine
6-carboxylate. |
| Pathway |
ec00300 Lysine biosynthesis
ec01100 Metabolic pathways |
| Orthology |
K03918 L-lysine 6-transaminase |
| Genes |
PCA: Pcar_2442
DPS: DP2333
MTU: Rv3290c(lat)
MTC: MT3389(lat)
MRA: MRA_3331(lat)
MTF: TBFG_13319
MTB: TBMG_03338(TBMG_03338.1)
MBO: Mb3318c(lat)
MBB: BCG_3319c(lat) BCG_3354c(lat')
MBT: JTY_3315(lat)
MPA: MAP3410c(lat)
MAV: MAV_4262
MSM: MSMEG_1764
MUL: MUL_2644(lat)
MVA: Mvan_1652
MGI: Mflv_4796
MAB: MAB_3646c
MMC: Mmcs_1272
MKM: Mkms_1289
MJL: Mjls_1301
MMI: MMAR_1243(lat)
NFA: nfa9840
RHA: RHA1_ro06277(lat)
RER: RER_21100(lat)
ROP: ROP_63400(lat)
SRT: Srot_1934
SRO: Sros_7678
FRA: Francci3_2873
FRE: Franean1_2373
FAL: FRAAL4414(lat)
SEN: SACE_0784(lat)
TBI: Tbis_2682
SRU: SRU_0799
SRM: SRM_00977(argD)
RMR: Rmar_2194
PHE: Phep_1211
FBA: FIC_01043
TAI: Taci_1141
STI: Sthe_2786
TTR: Tter_1717
ABI: Aboo_0464
 |
Reference Authors Title
Journal Organism
|
1 [PMID:5722275]
Soda K, Misono H, Yamamoto T.
L-Lysine:alpha-ketoglutarate aminotransferase. I. Identification of
a product, delta-1-piperideine-6-carboxylic acid.
Biochemistry. 7 (1968) 4102-9.
Flavobacterium fuscum |
Reference Authors Title
Journal Organism
|
2 [PMID:5722276]
Soda K, Misono H.
L-Lysine:alpha-ketoglutarate aminotransferase. II. Purification,
crystallization, and properties.
Biochemistry. 7 (1968) 4110-9.
Achrornobacter liquidurn, Flavobacterium flavescens, Flavobacterium
fuscum |
| Other DBs |
ExplorEnz - The Enzyme Database: 2.6.1.36
IUBMB Enzyme Nomenclature: 2.6.1.36
ExPASy - ENZYME nomenclature database: 2.6.1.36
BRENDA, the Enzyme Database: 2.6.1.36
CAS: 9054-68-6 |