KEGG   ENZYME: 2.6.1.40Help
Entry
EC 2.6.1.40                 Enzyme                                 

Name
(R)-3-amino-2-methylpropionate---pyruvate transaminase;
D-3-aminoisobutyrate---pyruvate transaminase;
beta-aminoisobutyrate-pyruvate aminotransferase;
D-3-aminoisobutyrate-pyruvate aminotransferase;
D-3-aminoisobutyrate-pyruvate transaminase;
(R)-3-amino-2-methylpropionate transaminase;
D-beta-aminoisobutyrate:pyruvate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase
Reaction(IUBMB)
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine [RN:R02050]
Reaction(KEGG)
Substrate
(R)-3-amino-2-methylpropanoate [CPD:C01205];
pyruvate [CPD:C00022]
Product
2-methyl-3-oxopropanoate [CPD:C00349];
L-alanine [CPD:C00041]
Comment
The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.22, (S)-3-amino-2-methylpropionate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.
History
EC 2.6.1.40 created 1972 (EC 2.6.1.61 created 1982, incorporated 2004) modified 2004
Orthology
K00827  
alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase
Genes
HSA: 
64902(AGXT2)
PTR: 
471573(AGXT2)
PPS: 
100982568(AGXT2)
GGO: 
101147587(AGXT2)
PON: 
100171524(AGXT2)
MCC: 
699250(AGXT2)
MCF: 
102140666(AGXT2)
MMU: 
268782(Agxt2)
RNO: 
83784(Agxt2)
CGE: 
100759906(Agxt2)
HGL: 
101714498(Agxt2)
TUP: 
102501713(AGXT2)
CFA: 
612589(AGXT2)
AML: 
100482092(AGXT2)
FCA: 
101097947(AGXT2)
PTG: 
102966139(AGXT2)
BTA: 
521553(AGXT2)
BOM: 
102269782(AGXT2)
PHD: 
102320044(AGXT2)
CHX: 
102176828(AGXT2)
OAS: 
101111660(AGXT2)
SSC: 
100513890(AGXT2)
CFR: 
102515152(AGXT2)
BACU: 
103010921(AGXT2)
LVE: 
103080731(AGXT2)
ECB: 
100053849(AGXT2)
MYB: 
102239222(AGXT2)
MYD: 
102773052(AGXT2)
PALE: 
102888844(AGXT2)
MDO: 
100020759(AGXT2)
SHR: 
100917044(AGXT2)
OAA: 
100078063(AGXT2)
GGA: 
431666(AGXT2)
MGP: 
TGU: 
100230972(AGXT2)
FAB: 
101810573(AGXT2)
PHI: 
102109437(AGXT2)
APLA: 
101799853(AGXT2)
FPG: 
101911080(AGXT2)
FCH: 
102052632(AGXT2)
CLV: 
102087277(AGXT2)
ASN: 
102375742(AGXT2)
AMJ: 
102559340(AGXT2)
PSS: 
102449032(AGXT2)
CMY: 
102930944(AGXT2)
ACS: 
100565387(agxt2)
PBI: 
103060614(AGXT2)
XTR: 
100491739(agxt2)
DRE: 
619269(agxt2)
TRU: 
MZE: 
XMA: 
LCM: 
102356225(AGXT2)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_T09B4.8(T09B4.8)
CBR: 
NVE: 
HMG: 
TAD: 
ATH: 
AT2G38400(AGT3) AT3G08860(PYD4) AT4G39660(AGT2)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0005s08380g POPTR_0006s10740g(POPTRDRAFT_866890) POPTR_0007s06190g(POPTRDRAFT_1082658) POPTR_0007s06700g(POPTRDRAFT_562721) POPTR_0016s13970g(POPTRDRAFT_835604)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os03t0171900-01(Os03g0171900) Os03t0338000-01(Os03g0338000) Os05t0475400-01(Os05g0475400)
OBR: 
BDI: 
SBI: 
SORBI_01g035960(SORBIDRAFT_01g035960) SORBI_01g045680(SORBIDRAFT_01g045680) SORBI_09g023310(SORBIDRAFT_09g023310)
ZMA: 
SITA: 
ATR: 
s00007p00206520(AMTR_s00007p00206520) s00010p00232210(AMTR_s00010p00232210)
SMO: 
PPP: 
CRE: 
VCN: 
CSL: 
CVR: 
MBR: 
ACAN: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:5773299]
  Authors
Kakimoto Y, Taniguchi K, Sano I.
  Title
D-beta-aminoisobutyrate:pyruvate aminotransferase in mammalian liver and excretion of beta-aminoisobutyrate by man.
  Journal
J. Biol. Chem. 244 (1969) 335-40.
Reference
2  [PMID:10989446]
  Authors
Tamaki N, Sakata SF, Matsuda K.
  Title
Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver.
  Journal
Methods. Enzymol. 324 (2000) 376-89.
  Sequence
[rno:83784]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37279-00-8

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