KEGG   ENZYME: 2.6.1.40Help
Entry
EC 2.6.1.40                 Enzyme                                 
Name
(R)-3-amino-2-methylpropionate---pyruvate transaminase;
D-3-aminoisobutyrate---pyruvate transaminase;
beta-aminoisobutyrate-pyruvate aminotransferase;
D-3-aminoisobutyrate-pyruvate aminotransferase;
D-3-aminoisobutyrate-pyruvate transaminase;
(R)-3-amino-2-methylpropionate transaminase;
D-beta-aminoisobutyrate:pyruvate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase
Reaction(IUBMB)
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine [RN:R02050]
Reaction(KEGG)
Substrate
(R)-3-amino-2-methylpropanoate [CPD:C01205];
pyruvate [CPD:C00022]
Product
2-methyl-3-oxopropanoate [CPD:C00349];
L-alanine [CPD:C00041]
Comment
The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.22, (S)-3-amino-2-methylpropionate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.
Orthology
K00827  
alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase
Genes
HSA: 
64902(AGXT2)
PTR: 
471573(AGXT2)
PPS: 
100982568(AGXT2)
GGO: 
101147587(AGXT2)
PON: 
100171524(AGXT2)
MCC: 
699250(AGXT2)
MMU: 
268782(Agxt2)
RNO: 
83784(Agxt2)
CFA: 
612589(AGXT2)
AML: 
100482092(AGXT2)
FCA: 
101097947(AGXT2)
BTA: 
521553(AGXT2)
SSC: 
100513890(AGXT2)
ECB: 
100053849
MDO: 
100020759
SHR: 
100917044(AGXT2)
OAA: 
100078063
GGA: 
431666(AGXT2)
MGP: 
100541842
TGU: 
100230972(AGXT2)
ACS: 
100565387
XTR: 
100491739
DRE: 
619269(agxt2)
TRU: 
101075075
BFO: 
BRAFLDRAFT_260217
CIN: 
100178847
SPU: 
594821
DME: 
Dmel_CG11241
DPO: 
Dpse_GA10859
DAN: 
Dana_GF23448
DER: 
Dere_GG13171
DPE: 
Dper_GL18115
DSE: 
Dsec_GM22081
DSI: 
Dsim_GD12056
DWI: 
Dwil_GK20568
DYA: 
Dyak_GE19492
DGR: 
Dgri_GH14768
DMO: 
Dmoj_GI11871
DVI: 
Dvir_GJ13565
AGA: 
AgaP_AGAP012404
AAG: 
AaeL_AAEL000640
CQU: 
CpipJ_CPIJ005222
NVI: 
100123739(NV14113)
TCA: 
658321
API: 
100163196
PHU: 
Phum_PHUM292860
ISC: 
IscW_ISCW020823
CEL: 
CELE_T09B4.8(T09B4.8)
CBR: 
CBG12888
NVE: 
NEMVE_v1g214753
HMG: 
100197706
TAD: 
TRIADDRAFT_63204
ATH: 
AT2G38400(AGT3) AT3G08860(PYD4) AT4G39660(AGT2)
ALY: 
ARALYDRAFT_490746 ARALYDRAFT_897023 ARALYDRAFT_903067
GMX: 
100170733 100780526 100804017
MTR: 
MTR_7g072420 MTR_8g091660
CSV: 
101208662 101210304
RCU: 
RCOM_0193980 RCOM_1230590
POP: 
POPTR_1082658 POPTR_835604 POPTR_866890
VVI: 
100243935 100251671 100258727
OSA: 
4331779 4332775 4339095
DOSA: 
Os03t0171900-01(Os03g0171900) Os03t0338000-01(Os03g0338000) Os05t0475400-01(Os05g0475400)
BDI: 
100821851 100824380 100846647
SBI: 
SORBI_01g035960(SORBIDRAFT_01g035960) SORBI_01g045680(SORBIDRAFT_01g045680) SORBI_09g023310(SORBIDRAFT_09g023310)
ZMA: 
100279249 100384690 100501001
SMO: 
SELMODRAFT_143081 SELMODRAFT_235068
PPP: 
PHYPADRAFT_178763
CRE: 
CHLREDRAFT_133057(AGT2)
VCN: 
VOLCADRAFT_79310
MBR: 
MONBRDRAFT_26129
NGR: 
NAEGRDRAFT_82452
 » show all
Taxonomy
Reference
1  [PMID:5773299]
  Authors
Kakimoto Y, Taniguchi K, Sano I.
  Title
D-beta-aminoisobutyrate:pyruvate aminotransferase in mammalian liver and excretion of beta-aminoisobutyrate by man.
  Journal
J. Biol. Chem. 244 (1969) 335-40.
  Organism
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno], Sus scofa [GN:ssc], Cavia porcellus
Reference
2  [PMID:10989446]
  Authors
Tamaki N, Sakata SF, Matsuda K.
  Title
Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver.
  Journal
Methods. Enzymol. 324 (2000) 376-89.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37279-00-8
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