KEGG   ENZYME: 2.6.1.58Help
Entry
EC 2.6.1.58                 Enzyme                                 

Name
phenylalanine(histidine) transaminase;
phenylalanine (histidine) aminotransferase;
phenylalanine(histidine):pyruvate aminotransferase;
histidine:pyruvate aminotransferase;
L-phenylalanine(L-histidine):pyruvate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-phenylalanine:pyruvate aminotransferase
Reaction(IUBMB)
L-phenylalanine + pyruvate = phenylpyruvate + L-alanine [RN:R00692]
Reaction(KEGG)
R00692;
(other) R09254
Show
Substrate
L-phenylalanine [CPD:C00079];
pyruvate [CPD:C00022]
Product
phenylpyruvate [CPD:C00166];
L-alanine [CPD:C00041]
Comment
L-Histidine and L-tyrosine can act instead of L-phenylalanine; in the reverse reaction, L-methionine, L-serine and L-glutamine can replace L-alanine.
History
EC 2.6.1.58 created 1978
Pathway
Tyrosine metabolism
Phenylalanine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Tropane, piperidine and pyridine alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K05821  
aromatic amino acid aminotransferase II
Genes
SCE: 
YHR137W(ARO9)
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B07220(NCAS0B07220)
NDI: 
NDAI_0B04550(NDAI0B04550)
TPF: 
TPHA_0O01520(TPHA0O01520)
TBL: 
TBLA_0B00990(TBLA0B00990)
TDL: 
TDEL_0F00900(TDEL0F00900)
PIC: 
PICST_34099(ARO9.1)
PGU: 
LEL: 
CAL: 
CTP: 
CDU: 
COT: 
CTEN: 
YLI: 
CLU: 
 » show all
Taxonomy
Reference
1  [PMID:14070]
  Authors
Minatogawa Y, Noguchi T, Kido R.
  Title
Species distribution and properties of hepatic phenylalanine (histidine):pyruvate aminotransferase.
  Journal
Hoppe. Seylers. Z. Physiol. Chem. 358 (1977) 59-67.
  Organism
Homo sapiens, Mus musculus, Rattus norvegicus, Canis familiaris, Sus scofa, Gallus gallus, Cavia porcellus, Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
72560-98-6

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