KEGG   ENZYME: 2.6.1.6Help
Entry
EC 2.6.1.6                  Enzyme                                 
Name
leucine transaminase;
L-leucine aminotransferase;
leucine 2-oxoglutarate transaminase;
leucine aminotransferase;
leucine-alpha-ketoglutarate transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-leucine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate [RN:R01090]
Reaction(KEGG)
R01090;
(other) R01214
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Substrate
L-leucine [CPD:C00123];
2-oxoglutarate [CPD:C00026]
Product
4-methyl-2-oxopentanoate [CPD:C00233];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. This enzyme differs from EC 2.6.1.42, branched-chain-amino-acid transaminase, in that it does not act on L-valine or L-isoleucine, although it does act on L-methionine. The mitochondrial form from rat liver differs in physical characteristics from the cytoplasmic form.
Pathway
Valine, leucine and isoleucine degradation
Valine, leucine and isoleucine biosynthesis
Pantothenate and CoA biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Reference
1  [PMID:4968655]
  Authors
Aki K, Ogawa K, Ichihara A.
  Title
Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver.
  Journal
Biochim. Biophys. Acta. 159 (1968) 276-84.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:974100]
  Authors
Ikeda T, Konishi Y, Ichihara A.
  Title
Transaminase of branched chain amino acids. XI. Leucine (methionine) transaminase of rat liver mitochondria.
  Journal
Biochim. Biophys. Acta. 445 (1976) 622-31.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9030-37-9
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