| Entry |
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| Name |
diaminobutyrate---2-oxoglutarate transaminase;
L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase;
2,4-diaminobutyrate 4-aminotransferase;
diaminobutyrate aminotransferase;
DABA aminotransferase;
DAB aminotransferase;
EctB;
diaminibutyric acid aminotransferase;
L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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| Sysname |
L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase
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| Reaction(IUBMB) |
L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate [RN: R06977]
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| Reaction(KEGG) |
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| Substrate |
L-2,4-diaminobutanoate [CPD: C03283];
2-oxoglutarate [CPD: C00026]
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| Product |
L-aspartate 4-semialdehyde [CPD: C00441];
L-glutamate [CPD: C00025]
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| Comment |
A pyridoxal-phosphate protein that requires potassium for activity [4]. In the proteobacterium Acinetobacter baumannii, this enzyme is cotranscribed with the neighbouring ddc gene that also encodes EC 4.1.1.86, diaminobutyrate decarboxylase. Differs from EC 2.6.1.46, diaminobutyrate---pyruvate transaminase, which has pyruvate as the amino-group acceptor. This is the first enzyme in the ectoine-biosynthesis pathway, the other enzymes involved being EC 2.3.1.178, diaminobutyrate acetyltransferase and EC 4.2.1.108, ectoine synthase [3,4].
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| Pathway |
| Glycine, serine and threonine metabolism | | Metabolic pathways | | Microbial metabolism in diverse environments |
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| Orthology |
| diaminobutyrate-2-oxoglutarate transaminase |
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| Genes |
EBT: | | ECA: | | PCT: | | PCC: | | PWA: | | PEC: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | PLU: | | SGL: | | ENT: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | DDC: | | DDD: | | DZE: | | XNE: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | RAH: | | RAQ: | | RAA: | | EBF: | | HIN: | | HIT: | | HIP: | | HIQ: | | HIF: | | HIL: | | HIU: | | HIE: | | HIZ: | | HDU: | | HAP: | | HSO: | | HSM: | | MSU: | | MHT: | | MHQ: | | APL: | | APJ: | | APA: | | ASU: | | ASI: | | GAN: | | BTO: | | XAL: | | VCH: | | VCE: | | VCJ: | | VCO: | | VCR: | | VCM: | | VCI: | | VCL: | | VVU: | | VVY: | | VVM: | | VPA: | | VPB: | | VHA: | | VSP: | | VEX: | | VEJ: | | VFU: | | VFI: | | VFM: | | PPR: | | VAN: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUU: | | PST: | | PSB: | | PSP: | | PFL: | | PFO: | | PFS: | | PFE: | | PFC: | | PPZ: | | PEN: | | PMY: | | PMK: | | PSA: | | PSZ: | | PSR: | | PSC: | | PSJ: | | PSH: | | PBA: | | PFV: | | CJA: | | AVN: | | ACI: | | ACD: | | ACB: | | ABM: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABH: | | ABAD: | | ACC: | | MCT: | | SDE: | | MAQ: | | MHC: | | MAD: | | PIN: | | PSY: | | TTU: | | MAH: | | FPH: | | FRT: | | TCX: | | TCY: | | MEJ: | | MEC: | | CYQ: | | NOC: | | NHL: | | NWA: | | TMB: | | AEH: | | HHA: | | HNA: | | HCH: | | CSA: | | HEL: | | ABO: | | ADI: | | MMW: | | MME: | | MPC: | | TOL: | | OCE: | | GPB: | | CVI: | | RSO: | | REH: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPR: | | BPZ: | | BPQ: | | BAM: | | BPH: | | BRH: | | BGD: | | BUK: | | BPX: | | BPA: | | BPAR: | | BBR: | | BBM: | | BBH: | | BPT: | | BAV: | | AXY: | | PUT: | | AKA: | | AAV: | | AAA: | | HAR: | | MMS: | | CFU: | | WSU: | | ANT: | | ARC: | | DSF: | | DOL: | | DAL: | | SCL: | | HOH: | | DBR: | | MLO: | | MCI: | | MOP: | | MAM: | | SME: | | SMQ: | | SMEG: | | SMEL: | | RHI: | | RTR: | | PHL: | | PZU: | | SIT: | | HNE: | | NPP: | | SAL: | | SSY: | | ACR: | | AMV: | | DIN: | | BLI: | | BLD: | | BHA: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BCU: | | BCX: | | BCF: | | BTL: | | BCL: | | BPU: | | BPF: | | BMQ: | | BMD: | | BMH: | | BSE: | | BCO: | | OIH: | | HHD: | | GYM: | | PPY: | | PPM: | | PPO: | | PMS: | | PMQ: | | PMW: | | PTA: | | CCB: | | COO: | | CCT: | | MSM: | | MSG: | | MUL: | | MVA: | | MGI: | | MSP: | | MAB: | | MMV: | | MMC: | | MKM: | | MJL: | | MJD: | | MMI: | | MCB: | | MLI: | | ASD: | | CHN: | | NFA: | | NCY: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | GBR: | | GPO: | | GOR: | | TPR: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | KSK: | | CMI: | | CMC: | | BFA: | | KSE: | | TFU: | | NDA: | | NAL: | | FRA: | | FRE: | | FAL: | | FSY: | | SEN: | | SVI: | | AMD: | | AMN: | | AMM: | | PDX: | | AMI: | | SAQ: | | ASE: | | CAI: | | SNA: | | RXY: | | TBE: | | SSM: | | SFC: | | SBU: | | SGP: | | OTE: | | RBA: | | PBS: | | SYP: | | AMR: | | CAN: | | GVI: | | ANA: | | NOS: | | AVA: | | CSG: | | CALT: | | LEP: | | GEI: | | CTHE: | | SCS: | | DLY: | | HAU: | | NDE: | | LFI: | | FSI: | | MCJ: | | MHI: | | MLA: | | HAL: | | HSL: | | HHI: | | HLA: | | HMU: | | HTU: | | NMG: | | HVO: | | HME: | | HJE: | | HBO: | | HXA: | | NAT: | | NPE: | | NOU: | | SOL: | | SIS: | | SIA: | | SIM: | | SID: | | SIY: | | SIN: | | SII: | | SIH: | | SIR: | | SIC: | | VDI: | | VMO: | | NMR: | | NIR: | | NKR: | | HAH: | |
» show all
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| Reference |
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| Authors |
Ikai H, Yamamoto S. |
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| Title |
Identification and analysis of a gene encoding L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase involved in the 1,3-diaminopropane production pathway in Acinetobacter baumannii. |
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| Journal |
J. Bacteriol. 179 (1997) 5118-25. |
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| Organism |
Acinetobacter baumannii |
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| Reference |
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| Authors |
Ikai H, Yamamoto S. |
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| Title |
Two genes involved in the 1,3-diaminopropane production pathway in Haemophilus influenzae. |
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| Journal |
Biol. Pharm. Bull. 21 (1998) 170-3. |
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| Organism |
Haemophilus influenzae [GN: hin] |
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| Reference |
3 |
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| Authors |
Peters, P., Galinski, E.A. and Truper, H.G. |
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| Title |
The biosynthesis of ectoine. |
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| Journal |
FEMS Microbiol. Lett. 71 (1990) 157-162. |
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| Reference |
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| Authors |
Ono H, Sawada K, Khunajakr N, Tao T, Yamamoto M, Hiramoto M, Shinmyo A, Takano M, Murooka Y. |
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| Title |
Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata. |
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| Journal |
J. Bacteriol. 181 (1999) 91-9. |
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| Organism |
Halomonas elongata |
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| Reference |
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| Authors |
Kuhlmann AU, Bremer E. |
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| Title |
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp. |
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| Journal |
Appl. Environ. Microbiol. 68 (2002) 772-83. |
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| Organism |
Bacillus pasteurii |
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| Reference |
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| Authors |
Louis P, Galinski EA. |
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| Title |
Characterization of genes for the biosynthesis of the compatible solute ectoine from Marinococcus halophilus and osmoregulated expression in Escherichia coli. |
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| Journal |
Microbiology. 143 ( Pt 4) (1997) 1141-9. |
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| Organism |
Marinococcus halophilus |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 196622-96-5 |
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