KEGG   ENZYME: 2.6.1.80Help
Entry
EC 2.6.1.80                 Enzyme                                 

Name
nicotianamine aminotransferase;
NAAT;
NAAT-I;
NAAT-II;
NAAT-III;
nicotianamine transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
nicotianamine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate [RN:R07277]
Reaction(KEGG)
Substrate
nicotianamine [CPD:C05324];
2-oxoglutarate [CPD:C00026]
Product
3''-deamino-3''-oxonicotianamine [CPD:C15486];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. This enzyme is produced by grasses. They secrete both the nicotianamine and the transaminated product into the soil around them. Both compounds chelate iron(II) and iron(III); these chelators, called mugineic acid family phytosiderophores, are taken up by the grass, which is thereby supplied with iron.
History
EC 2.6.1.80 created 2005
Orthology
K14271  
nicotianamine aminotransferase
Genes
ZMA: 
100144299(naat1)
Taxonomy
Reference
1
  Authors
Kanazawa, K., Higuchi, K., Nishizawa, N.-K., Fushiya, S., Chino, M. and Mori, S.
  Title
Nicotianamine aminotransferase activities are correlated with the phytosiderophore secretions under Fe-deficient conditions in Gramineae.
  Journal
J. Exp. Bot. 45 (1994) 1903-1906.
Reference
2  [PMID:10557244]
  Authors
Takahashi M, Yamaguchi H, Nakanishi H, Shioiri T, Nishizawa NK, Mori S.
  Title
Cloning two genes for nicotianamine aminotransferase, a critical enzyme in iron acquisition (Strategy II) in graminaceous plants.
  Journal
Plant. Physiol. 121 (1999) 947-56.
  Organism
Hordeum vulgare
  Sequence
Reference
3  [PMID:14699112]
  Authors
Schaaf G, Ludewig U, Erenoglu BE, Mori S, Kitahara T, von Wiren N.
  Title
ZmYS1 functions as a proton-coupled symporter for phytosiderophore- and nicotianamine-chelated metals.
  Journal
J. Biol. Chem. 279 (2004) 9091-6.
  Organism
Zea mays
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
154907-64-9

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