| Entry |
|
|---|
| Name |
LL-diaminopimelate aminotransferase;
LL-diaminopimelate transaminase;
LL-DAP aminotransferase;
LL-DAP-AT |
|---|
| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
 |
|---|
| Sysname |
LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase |
|---|
| Reaction(IUBMB) |
LL-2,6-diaminoheptanedioate + 2-oxoglutarate =
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O
[RN:R07613] |
|---|
| Reaction(KEGG) |
R07613
 |
|---|
| Substrate |
LL-2,6-diaminoheptanedioate [CPD:C00666];
2-oxoglutarate [CPD:C00026] |
|---|
| Product |
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate [CPD:C03972];
L-glutamate [CPD:C00025];
H2O [CPD:C00001] |
|---|
| Comment |
A pyridoxal-phosphate enzyme. In vivo, the reaction occurs in the
opposite direction to that shown above. This is one of the final
steps in the lysine-biosynthesis pathway of plants (ranging from
mosses to flowering plants). meso-Diaminoheptanedioate, an isomer of
LL-2,6-diaminoheptanedioate, and the structurally related compounds
lysine and ornithine are not substrates. 2-Oxoglutarate cannot be
replaced by oxaloacetate or pyruvate. It is not yet known if the
substrate of the biosynthetic reaction is the cyclic or acyclic form
of tetrahydropyridine-2,6-dicarboxylate. |
|---|
| Pathway |
ec00300 Lysine biosynthesis
ec01110 Biosynthesis of secondary metabolites |
|---|
| Orthology |
K10206 LL-diaminopimelate aminotransferase |
|---|
| Genes |
ATH: AT4G33680(AGD2)
POP: POPTR_202265 POPTR_710171
RCU: RCOM_0399800 RCOM_1381600
VVI: 100244650 100253830 100267796
OSA: 4332563(Os03g0299900)
SBI: SORBI_01g038010 SORBI_01g044130
ZMA: 100283445
PPP: PHYPADRAFT_121808
CRE: CHLREDRAFT_129557(DPA1)
OLU: OSTLU_30412
CME: CMN323C
PTI: PHATRDRAFT_22909
TPS: THAPSDRAFT_31394
GSU: GSU0162
GME: Gmet_0213
GUR: Gura_0238
GLO: Glov_3040
GBM: Gbem_4052
GEO: Geob_1134
GEM: GM21_4142
PCA: Pcar_2423
PPD: Ppro_3061
DVU: DVU1655
DVL: Dvul_1431
DVM: DvMF_0361
DDE: Dde_1970
DDS: Ddes_1151
DMA: DMR_22010
DSA: Desal_1952
LIP: LI0435(aspC)
DBA: Dbac_0704
DRT: Dret_1351
DPS: DP2165
DAK: DaAHT2_2137
DAL: Dalk_0414
DAT: HRM2_02680
SAT: SYN_00168
SFU: Sfum_0054
CTH: Cthe_3101
CPY: Cphy_0631
SLP: Slip_0851
AFN: Acfer_0333
DSY: DSY3402
DHD: Dhaf_4564
DRM: Dred_1695
DAE: Dtox_2324
PTH: PTH_1799
DAU: Daud_1603
TJR: TherJR_1813
HMO: HM1_0993
EEL: EUBELI_00672
ERE: EUBREC_2541
CHY: CHY_1492
MTA: Moth_0889
ADG: Adeg_1381
NTH: Nther_1272
HOR: Hore_11560
KSE: Ksed_00770
CWO: Cwoe_3257
CTR: CT390(aspC)
CTA: CTA_0425(aspC)
CTB: CTL0646(dapL)
CTL: CTLon_0643(dapL)
CTJ: JALI_3891(dapL)
CMU: TC0669
CPN: CPn0495(aspC)
CPA: CP0259
CPJ: CPj0495(aspC)
CPT: CpB0515
CCA: CCA00249
CAB: CAB245
CFE: CF0757(aspC)
PCU: pc0685(aspC)
WCH: wcw_0764(aspC3)
LIL: LA_0776
LIC: LIC12841(ywfG)
LBJ: LBJ_0733
LBL: LBL_2347
LBI: LEPBI_I1028
LBF: LBF_0994
BTH: BT_0547
BFR: BF2643
BFS: BF2666
BVU: BVU_4005
PDI: BDI_0321
APS: CFPG_571
PRU: PRU_1974
FSU: Fisuc_1814
OTE: Oter_4620
PLM: Plim_3995
EMI: Emin_1014
RSD: TGRD_639
SYN: sll0480
SYW: SYNW2147
SYC: syc0687_c(aspB)
SYF: Synpcc7942_0853
SYD: Syncc9605_0311
SYE: Syncc9902_2031
SYG: sync_0372(aspB)
SYR: SynRCC307_2179
SYX: SynWH7803_0370
SYP: SYNPCC7002_A1203
CYA: CYA_2460
CYB: CYB_1421(aspB)
TEL: tll2102
MAR: MAE_46460
CYT: cce_2605
CYP: PCC8801_0494
CYC: PCC7424_4059
CYN: Cyan7425_4424
CYH: Cyan8802_0509
CYU: UCYN_09940
GVI: glr4108
ANA: all4327 alr5103
NPU: Npun_R3615
AVA: Ava_1277 Ava_2354
NAZ: Aazo_1424
PMA: Pro1655
PMM: PMM1500
PMT: PMT1791
PMN: PMN2A_1066
PMI: PMT9312_1592
PMB: A9601_17031
PMC: P9515_16801
PMF: P9303_23741
PMG: P9301_16911
PMH: P9215_17681
PMJ: P9211_16221
PME: NATL1_19411
TER: Tery_0487 Tery_3293
AMR: AM1_1880
DET: DET0739
DEH: cbdb_A714(cbdbA714)
DEB: DehaBAV1_0669
DEV: DhcVS_646
DEG: DehalGT_0630
AAE: aq_273(aspC4)
HYA: HY04AAS1_0487
HTH: HTH_0357
TAL: Thal_1518
DTH: DICTH_0944
DTU: Dtur_1080
TYE: THEYE_A0137
MTH: MTH52
MST: Msp_0924
MSI: Msm_1455
MRU: mru_0941(dapL)
 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:16361515]
Hudson AO, Singh BK, Leustek T, Gilvarg C.
An LL-diaminopimelate aminotransferase defines a novel variant of
the lysine biosynthesis pathway in plants.
Plant. Physiol. 140 (2006) 292-301.
Arabidopsis thaliana [GN:ath] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 2.6.1.83
IUBMB Enzyme Nomenclature: 2.6.1.83
ExPASy - ENZYME nomenclature database: 2.6.1.83
BRENDA, the Enzyme Database: 2.6.1.83
CAS: 949001-34-7 |
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