KEGG   ENZYME: 2.6.1.84Help
Entry
EC 2.6.1.84                 Enzyme                                 

Name
arginine---pyruvate transaminase;
arginine:pyruvate transaminase;
AruH;
ATase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-arginine:pyruvate aminotransferase
Reaction(IUBMB)
L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine [RN:R08197]
Reaction(KEGG)
Substrate
L-arginine [CPD:C00062];
pyruvate [CPD:C00022]
Product
5-guanidino-2-oxopentanoate [CPD:C03771];
L-alanine [CPD:C00041]
Comment
A pyridoxal-phosphate protein. While L-arginine is the best substrate, the enzyme exhibits broad substrate specificity, with L-lysine, L-methionine, L-leucine, L-ornithine and L-glutamine also able to act as substrates, but more slowly. Pyruvate cannot be replaced by 2-oxoglutarate as amino-group acceptor. This is the first catalytic enzyme of the arginine transaminase pathway for L-arginine utilization in Pseudomonas aeruginosa. This pathway is only used when the major route of arginine catabolism, i.e. the arginine succinyltransferase pathway, is blocked.
History
EC 2.6.1.84 created 2007
Pathway
Arginine and proline metabolism
Metabolic pathways
Orthology
K12252  
arginine:pyruvate transaminase
Genes
PAE: 
PA4976(aruH)
PAEV: 
PAEI: 
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PAEB: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
PAEG: 
PAEC: 
PAEO: 
PRE: 
PPU: 
PP_3721(aspC)
PPF: 
PPG: 
PPW: 
PPT: 
PPB: 
PPI: 
PPX: 
T1E_1732(aspC)
PPUH: 
PPUT: 
PPUN: 
PP4_21010(aspC)
PPUD: 
PMON: 
PMOT: 
PMOS: 
PPJ: 
PFL: 
PPRC: 
PPRO: 
PFO: 
PFE: 
PFN: 
PFW: 
PFB: 
PMAN: 
PTV: 
PEN: 
PSEEN3003(aspC)
PBA: 
PBC: 
PPUU: 
PDR: 
PSV: 
PSK: 
PKC: 
PKB_0124(aspc1)
PCH: 
PCZ: 
PCP: 
PALK: 
PSEM: 
PSEC: 
PSOS: 
AAL: 
AAUS: 
SAGA: 
MTHD: 
CSA: 
HEL: 
HELO_2764(aspC1)
HHU: 
BCEN: 
BCT: 
BUG: 
BGE: 
BGF: 
BUQ: 
BXE: 
BXB: 
BPX: 
BPY: 
BFN: 
MLO: 
MCI: 
MOP: 
MAM: 
MAMO: 
MES: 
HOE: 
AAK: 
SME: 
SMK: 
SMQ: 
SMX: 
SMI: 
SMEG: 
SMEL: 
SMER: 
SMD: 
RHI: 
SFH: 
SFD: 
SIX: 
EAD: 
EAH: 
NGL: 
NGG: 
SHZ: 
MEY: 
MAAD: 
SIL: 
SIT: 
RMB: 
JAN: 
RDE: 
RD1_3185(aspC)
RLI: 
PAMI: 
PGA: 
PGL: 
PGD: 
OAT: 
OAR: 
OTM: 
OSB_16290(aruH)
LMD: 
RED: 
PTP: 
MALG: 
LAP: 
DAA: 
YAN: 
ABS: 
ABQ: 
 » show all
Taxonomy
Reference
1  [PMID:17416668]
  Authors
Yang Z, Lu CD.
  Title
Characterization of an arginine:pyruvate transaminase in arginine catabolism of Pseudomonas aeruginosa PAO1.
  Journal
J. Bacteriol. 189 (2007) 3954-9.
  Sequence
[pae:PA4976]
Reference
2  [PMID:17416670]
  Authors
Yang Z, Lu CD.
  Title
Functional genomics enables identification of genes of the arginine transaminase pathway in Pseudomonas aeruginosa.
  Journal
J. Bacteriol. 189 (2007) 3945-53.
  Sequence
[pae:PA4976]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system