2-amino-4-deoxychorismate synthase;
ADIC synthase;
2-amino-2-deoxyisochorismate synthase;
SgcD

Transferases;
Transferring nitrogenous groups;
Transaminases

(2S)-2-amino-4-deoxychorismate:2-oxoglutarate aminotransferase

(2S)-2-amino-4-deoxychorismate + L-glutamate = chorismate + L-glutamine [RN:R08956]

R08956

(2S)-2-amino-4-deoxychorismate [CPD:C18054];
L-glutamate [CPD:C00025]

Requires Mg2+. The reaction occurs in the reverse direction to that shown above. In contrast to most anthranilate-synthase I (ASI) homologues, this enzyme is not inhibited by tryptophan. In Streptomyces globisporus, the sequential action of this enzyme and EC 1.3.99.24, 2-amino-4-deoxychorismate dehydrogenase, leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2]. In certain Pseudomonads the enzyme participates in the biosynthesis of phenazine, a precursor for several compounds with antibiotic activity [3,4].

1  [PMID:18182490]

Van Lanen SG, Lin S, Shen B.

Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism.

Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 494-9.

2

Yu, L., Mah, S., Otani, T. and Dedon, P.

The benzoxazolinate of C-1027 confers intercalative DNA binding.

J. Am. Chem. Soc. 117 (1995) 8877-8878.

3  [PMID:11562236]

McDonald M, Mavrodi DV, Thomashow LS, Floss HG.

Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid.

J. Am. Chem. Soc. 123 (2001) 9459-60.

Pseudomonas fluorescens [GN:pfl pfo pfs]

4  [PMID:15008629]

Laursen JB, Nielsen J.

Phenazine natural products: biosynthesis, synthetic analogues, and biological activity.

Chem. Rev. 104 (2004) 1663-86.